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@ARTICLE{Schrder:155679,
      author       = {Schröder, Gunnar and Levitt, Michael and Brunger, Axel T.},
      title        = {{D}eformable elastic network refinement for low-resolution
                      macromolecular crystallography},
      journal      = {Acta crystallographica / D},
      volume       = {70},
      number       = {9},
      issn         = {1399-0047},
      address      = {Copenhagen},
      publisher    = {Munksgaard},
      reportid     = {FZJ-2014-04732},
      pages        = {2241 - 2255},
      year         = {2014},
      abstract     = {Crystals of membrane proteins and protein complexes often
                      diffract to low resolution owing to their intrinsic
                      molecular flexibility, heterogeneity or the mosaic spread of
                      micro-domains. At low resolution, the building and
                      refinement of atomic models is a more challenging task. The
                      deformable elastic network (DEN) refinement method developed
                      previously has been instrumental in the determinion of
                      several structures at low resolution. Here, DEN refinement
                      is reviewed, recommendations for its optimal usage are
                      provided and its limitations are discussed. Representative
                      examples of the application of DEN refinement to challenging
                      cases of refinement at low resolution are presented. These
                      cases include soluble as well as membrane proteins
                      determined at limiting resolutions ranging from 3 to 7 Å.
                      Potential extensions of the DEN refinement technique and
                      future perspectives for the interpretation of low-resolution
                      crystal structures are also discussed.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000341819500001},
      pubmed       = {pmid:25195739},
      doi          = {10.1107/S1399004714016496},
      url          = {https://juser.fz-juelich.de/record/155679},
}