%0 Thesis
%A Kronenberg, U.
%T Synthesis and radiofluorination of putative NMDA receptor ligands
%V 4338
%N Juel-4338
%I Univ. Köln
%V Dr. (Univ.)
%C Jülich
%M PreJuSER-15864
%M Juel-4338
%B Berichts des Forschungszentrums Jülich
%P III, 95 p.
%D 2010
%Z Record converted from JUWEL: 18.07.2013
%Z Köln, Univ., Diss., 2010
%X In the course of this work on the synthesis of radioligands for the NMDA receptor the
%X authentic standards and labeling precursors of four compounds with an amidine structure was performed.
%X Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoesters used for the synthesis were obtained from their
%X nitriles in a Pinner synthesis, while 2-hydroxybenzylamine was synthesized in a
%X reduction of 2-hydroxybenzonitrile using borane as a reducing agent. After a coupling
%X reaction of the amine and the imidoester in DMF using triethylamine as base the
%X precursors were obtained in good yields and purified by crystallization from methanol.
%X The cyclic standard compound was synthesized directly from 2-(bromomethyl)-
%X benzonitrile and 2-hydroxybenzylamine in a ring closing reaction. Similar to
%X the other precursors, crystallization from methanol produced a pure compound....
%F PUB:(DE-HGF)11 ; PUB:(DE-HGF)3
%9 Dissertation / PhD ThesisBook
%U https://juser.fz-juelich.de/record/15864