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000015864 1001_ $$0P:(DE-Juel1)VDB89462$$aKronenberg, U.$$b0$$eCorresponding author$$uFZJ
000015864 245__ $$aSynthesis and radiofluorination of putative NMDA receptor ligands
000015864 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2010
000015864 300__ $$aIII, 95 p.
000015864 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis
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000015864 3367_ $$02$$2EndNote$$aThesis
000015864 3367_ $$2DRIVER$$adoctoralThesis
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000015864 3367_ $$2ORCID$$aDISSERTATION
000015864 4900_ $$aBerichts des Forschungszentrums Jülich$$v4338
000015864 502__ $$aKöln, Univ., Diss., 2010$$bDr. (Univ.)$$cUniv. Köln$$d2010
000015864 500__ $$aRecord converted from JUWEL: 18.07.2013
000015864 500__ $$aRecord converted from VDB: 12.11.2012
000015864 520__ $$aIn the course of this work on the synthesis of radioligands for the NMDA receptor the
authentic standards and labeling precursors of four compounds with an amidine structure was performed.
Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoesters used for the synthesis were obtained from their
nitriles in a Pinner synthesis, while 2-hydroxybenzylamine was synthesized in a
reduction of 2-hydroxybenzonitrile using borane as a reducing agent. After a coupling
reaction of the amine and the imidoester in DMF using triethylamine as base the
precursors were obtained in good yields and purified by crystallization from methanol.
The cyclic standard compound was synthesized directly from 2-(bromomethyl)-
benzonitrile and 2-hydroxybenzylamine in a ring closing reaction. Similar to
the other precursors, crystallization from methanol produced a pure compound....
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000015864 655_7 $$aHochschulschrift$$xDissertation (Univ.)
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