TY  - THES
AU  - Kronenberg, U.
TI  - Synthesis and radiofluorination of putative NMDA receptor ligands
VL  - 4338
IS  - Juel-4338
PB  - Univ. Köln
VL  - Dr. (Univ.)
CY  - Jülich
M1  - PreJuSER-15864
M1  - Juel-4338
T2  - Berichts des Forschungszentrums Jülich
SP  - III, 95 p.
PY  - 2010
N1  - Record converted from JUWEL: 18.07.2013
N1  - Köln, Univ., Diss., 2010
AB  - In the course of this work on the synthesis of radioligands for the NMDA receptor the
AB  - authentic standards and labeling precursors of four compounds with an amidine structure was performed.
AB  - Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoesters used for the synthesis were obtained from their
AB  - nitriles in a Pinner synthesis, while 2-hydroxybenzylamine was synthesized in a
AB  - reduction of 2-hydroxybenzonitrile using borane as a reducing agent. After a coupling
AB  - reaction of the amine and the imidoester in DMF using triethylamine as base the
AB  - precursors were obtained in good yields and purified by crystallization from methanol.
AB  - The cyclic standard compound was synthesized directly from 2-(bromomethyl)-
AB  - benzonitrile and 2-hydroxybenzylamine in a ring closing reaction. Similar to
AB  - the other precursors, crystallization from methanol produced a pure compound....
LB  - PUB:(DE-HGF)11 ; PUB:(DE-HGF)3
UR  - https://juser.fz-juelich.de/record/15864
ER  -