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| 001 | 15864 | ||
| 005 | 20200610184248.0 | ||
| 024 | 7 | _ | |2 ISSN |a 0944-2952 |
| 024 | 7 | _ | |2 Handle |a 2128/4361 |
| 037 | _ | _ | |a PreJuSER-15864 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 088 | 1 | _ | |a Juel-4338 |
| 088 | _ | _ | |a Juel-4338 |2 JUEL |
| 100 | 1 | _ | |0 P:(DE-Juel1)VDB89462 |a Kronenberg, U. |b 0 |e Corresponding author |u FZJ |
| 245 | _ | _ | |a Synthesis and radiofluorination of putative NMDA receptor ligands |
| 260 | _ | _ | |a Jülich |b Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag |c 2010 |
| 300 | _ | _ | |a III, 95 p. |
| 336 | 7 | _ | |0 PUB:(DE-HGF)11 |2 PUB:(DE-HGF) |a Dissertation / PhD Thesis |
| 336 | 7 | _ | |0 PUB:(DE-HGF)3 |2 PUB:(DE-HGF) |a Book |
| 336 | 7 | _ | |0 2 |2 EndNote |a Thesis |
| 336 | 7 | _ | |2 DRIVER |a doctoralThesis |
| 336 | 7 | _ | |2 BibTeX |a PHDTHESIS |
| 336 | 7 | _ | |2 DataCite |a Output Types/Dissertation |
| 336 | 7 | _ | |2 ORCID |a DISSERTATION |
| 490 | 0 | _ | |a Berichts des Forschungszentrums Jülich |v 4338 |
| 500 | _ | _ | |a Record converted from JUWEL: 18.07.2013 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 502 | _ | _ | |a Köln, Univ., Diss., 2010 |b Dr. (Univ.) |c Univ. Köln |d 2010 |
| 520 | _ | _ | |a In the course of this work on the synthesis of radioligands for the NMDA receptor the
authentic standards and labeling precursors of four compounds with an amidine structure was performed.
Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoesters used for the synthesis were obtained from their
nitriles in a Pinner synthesis, while 2-hydroxybenzylamine was synthesized in a
reduction of 2-hydroxybenzonitrile using borane as a reducing agent. After a coupling
reaction of the amine and the imidoester in DMF using triethylamine as base the
precursors were obtained in good yields and purified by crystallization from methanol.
The cyclic standard compound was synthesized directly from 2-(bromomethyl)-
benzonitrile and 2-hydroxybenzylamine in a ring closing reaction. Similar to
the other precursors, crystallization from methanol produced a pure compound.... |
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| 655 | _ | 7 | |a Hochschulschrift |x Dissertation (Univ.) |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/15864/files/J%C2%A9%C6%A1l_4338_Kronenberg.pdf |y OpenAccess |
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| 970 | _ | _ | |a VDB:(DE-Juel1)129248 |
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| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a JUWEL |
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| 980 | 1 | _ | |a FullTexts |
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