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000015880 084__ $$2WoS$$aElectrochemistry
000015880 084__ $$2WoS$$aMaterials Science, Multidisciplinary
000015880 1001_ $$0P:(DE-Juel1)VDB83419$$aZhang, B.$$b0$$uFZJ
000015880 245__ $$aImproved NiSi0.8Ge0.2/Si0.8Ge0.2 Contacs by C+ Pre-Implantation
000015880 260__ $$aPennington, NJ$$bSoc.$$c2011
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000015880 440_0 $$013562$$aElectrochemical and Solid State Letters$$v14$$x1099-0062$$y7
000015880 500__ $$3POF3_Assignment on 2016-02-29
000015880 500__ $$aThis work was supported by the German Federal Ministry of Education and Research via the MEDEA+ project DECI-SIF(2T104). Additional funding was received by the Nanosil network from the European Community (FP7 grant No. 216171). B. Zhang thanks the National Natural Science Foundation of China under Grant No. 61006088 and, together with W. Yu to the China Scholarship Council for the financial support.
000015880 520__ $$aThis open-label extension evaluated the long-term efficacy and tolerability of rufinamide in patients with Lennox-Gastaut syndrome (LGS) who had previously completed a 12-week double-blind study.In total, 124 patients (aged 4-37 years), receiving 1-3 concomitant antiepileptic drugs, were treated with rufinamide approximately 25-60 mg/kg/day. Efficacy was assessed by seizure frequency; tolerability by adverse events (AEs) and laboratory tests.Overall, patients were treated with rufinamide for a median (range) of 432 (10-1149) days. Reductions in seizure frequency were observed throughout the study; during the last 12 months of treatment, 41.0% and 47.9% of patients had > or = 50% reduction in total and tonic-atonic seizure frequency, respectively. The most common AEs were vomiting (30.6%) and pyrexia (25.8%).In this open-label extension, rufinamide appeared to be an effective long-term adjunctive therapy for the treatment of LGS-associated seizures in children and young adults.
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000015880 7001_ $$0P:(DE-Juel1)125569$$aBuca, D.$$b3$$uFZJ
000015880 7001_ $$0P:(DE-Juel1)125595$$aHolländer, B.$$b4$$uFZJ
000015880 7001_ $$0P:(DE-HGF)0$$aHartmann, J.M.$$b5
000015880 7001_ $$0P:(DE-HGF)0$$aZhang, M.$$b6
000015880 7001_ $$0P:(DE-HGF)0$$aWang, X.$$b7
000015880 7001_ $$0P:(DE-Juel1)VDB4959$$aMantl, S.$$b8$$uFZJ
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