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000015918 084__ $$2WoS$$aNeurosciences
000015918 084__ $$2WoS$$aPsychiatry
000015918 1001_ $$0P:(DE-HGF)0$$aChase, H.W.$$b0
000015918 245__ $$aThe Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis
000015918 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2011
000015918 300__ $$a785 - 793
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000015918 440_0 $$011361$$aBiological Psychiatry$$v70$$x0006-3223$$y8
000015918 500__ $$aThis work was supported by a Medical Research Council grant (number G0701456; LH), the Human Brain Project (R01-MH074457-01A1; SBE, ARL), and the Helmholtz Alliance on Systems Biology ("Human Brain Model"; SBE). The authors report no biomedical financial interests or potential conflicts of interest.
000015918 520__ $$aThe capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed.Appropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation.Cue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving.These results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.
000015918 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000015918 65320 $$2Author$$aAddiction
000015918 65320 $$2Author$$acraving
000015918 65320 $$2Author$$acue
000015918 65320 $$2Author$$aimaging
000015918 65320 $$2Author$$ameta-analysis
000015918 65320 $$2Author$$areactivity
000015918 650_2 $$2MeSH$$aAlgorithms
000015918 650_2 $$2MeSH$$aBehavior, Addictive: physiopathology
000015918 650_2 $$2MeSH$$aBrain: drug effects
000015918 650_2 $$2MeSH$$aBrain: physiology
000015918 650_2 $$2MeSH$$aBrain Mapping: methods
000015918 650_2 $$2MeSH$$aBrain Mapping: psychology
000015918 650_2 $$2MeSH$$aCues
000015918 650_2 $$2MeSH$$aDrug-Seeking Behavior: physiology
000015918 650_2 $$2MeSH$$aHumans
000015918 650_2 $$2MeSH$$aPatient Acceptance of Health Care: psychology
000015918 650_7 $$2WoSType$$aJ
000015918 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b1$$uFZJ
000015918 7001_ $$0P:(DE-HGF)0$$aLaird, A.R.$$b2
000015918 7001_ $$0P:(DE-HGF)0$$aHogarth, L.$$b3
000015918 773__ $$0PERI:(DE-600)1499907-9$$a10.1016/j.biopsych.2011.05.025$$gVol. 70, p. 785 - 793$$p785 - 793$$q70<785 - 793$$tBiological psychiatry$$v70$$x0006-3223$$y2011
000015918 8567_ $$uhttp://dx.doi.org/10.1016/j.biopsych.2011.05.025
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000015918 9141_ $$y2011
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