TY  - JOUR
AU  - Chase, H.W.
AU  - Eickhoff, S.B.
AU  - Laird, A.R.
AU  - Hogarth, L.
TI  - The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis
JO  - Biological psychiatry
VL  - 70
SN  - 0006-3223
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-15918
SP  - 785 - 793
PY  - 2011
N1  - This work was supported by a Medical Research Council grant (number G0701456; LH), the Human Brain Project (R01-MH074457-01A1; SBE, ARL), and the Helmholtz Alliance on Systems Biology ("Human Brain Model"; SBE). The authors report no biomedical financial interests or potential conflicts of interest.
AB  - The capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed.Appropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation.Cue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving.These results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.
KW  - Algorithms
KW  - Behavior, Addictive: physiopathology
KW  - Brain: drug effects
KW  - Brain: physiology
KW  - Brain Mapping: methods
KW  - Brain Mapping: psychology
KW  - Cues
KW  - Drug-Seeking Behavior: physiology
KW  - Humans
KW  - Patient Acceptance of Health Care: psychology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21757184
UR  - <Go to ISI:>//WOS:000296026600015
DO  - DOI:10.1016/j.biopsych.2011.05.025
UR  - https://juser.fz-juelich.de/record/15918
ER  -