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@ARTICLE{Chase:15918,
      author       = {Chase, H.W. and Eickhoff, S.B. and Laird, A.R. and Hogarth,
                      L.},
      title        = {{T}he {N}eural {B}asis of {D}rug {S}timulus {P}rocessing
                      and {C}raving: {A}n {A}ctivation {L}ikelihood {E}stimation
                      {M}eta-{A}nalysis},
      journal      = {Biological psychiatry},
      volume       = {70},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-15918},
      pages        = {785 - 793},
      year         = {2011},
      note         = {This work was supported by a Medical Research Council grant
                      (number G0701456; LH), the Human Brain Project
                      (R01-MH074457-01A1; SBE, ARL), and the Helmholtz Alliance on
                      Systems Biology ("Human Brain Model"; SBE). The authors
                      report no biomedical financial interests or potential
                      conflicts of interest.},
      abstract     = {The capacity of drug cues to elicit drug-seeking behavior
                      is believed to play a fundamental role in drug dependence;
                      yet the neurofunctional basis of human drug cue-reactivity
                      is not fully understood. We performed a meta-analysis to
                      identify brain regions that are consistently activated by
                      presentation of drug cues. Studies involving
                      treatment-seeking and nontreatment-seeking substance users
                      were contrasted to determine whether there were consistent
                      differences in the neural response to drug cues between
                      these populations. Finally, to assess the neural basis of
                      craving, consistency across studies in brain regions that
                      show correlated activation with craving was
                      assessed.Appropriate studies, assessing the effect of
                      drug-related cues or manipulations of drug craving in
                      drug-user populations across the whole brain, were obtained
                      via the PubMed database and literature search. Activation
                      likelihood estimation, a method of quantitative
                      meta-analysis that estimates convergence across experiments
                      by modeling the spatial uncertainty of neuroimaging data,
                      was used to identify consistent regions of
                      activation.Cue-related activation was observed in the
                      ventral striatum (across both subgroups), amygdala (in the
                      treatment-seeking subgroup and overall), and orbitofrontal
                      cortex (in the nontreatment-seeking subgroup and overall)
                      but not insula cortex. Although a different pattern of
                      frontal and temporal lobe activation between the subgroups
                      was observed, these differences were not significant.
                      Finally, right amygdala and left middle frontal gyrus
                      activity were positively associated with craving.These
                      results substantiate the key neural substrates underlying
                      reactivity to drug cues and drug craving.},
      keywords     = {Algorithms / Behavior, Addictive: physiopathology / Brain:
                      drug effects / Brain: physiology / Brain Mapping: methods /
                      Brain Mapping: psychology / Cues / Drug-Seeking Behavior:
                      physiology / Humans / Patient Acceptance of Health Care:
                      psychology / J (WoSType)},
      cin          = {INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Neurosciences / Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21757184},
      UT           = {WOS:000296026600015},
      doi          = {10.1016/j.biopsych.2011.05.025},
      url          = {https://juser.fz-juelich.de/record/15918},
}