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000016158 0247_ $$2DOI$$a10.1080/17470919.2011.579800
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000016158 1001_ $$0P:(DE-HGF)0$$aDerntl, B.$$b0
000016158 245__ $$aNeural correlates of social approach and withdrawal in patients with major depression
000016158 260__ $$aNew York [u.a.]$$bPsychology Press$$c2011
000016158 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000016158 440_0 $$019022$$aSocial Neuroscience$$v6$$x1747-0919$$y5
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000016158 520__ $$aSuccessful human interaction is based on correct recognition, interpretation, and appropriate reaction to facial affect. In depression, social skill deficits are among the most restraining symptoms leading to social withdrawal, thereby aggravating social isolation and depressive affect. Dysfunctional approach and withdrawal tendencies to emotional stimuli have been documented, but the investigation of their neural underpinnings has received limited attention. We performed an fMRI study including 15 depressive patients and 15 matched, healthy controls. All subjects performed two tasks, an implicit joystick task as well as an explicit rating task, both using happy, neutral, and angry facial expressions. Behavioral data analysis indicated a significant group effect, with depressed patients showing more withdrawal than controls. Analysis of the functional data revealed significant group effects for both tasks. Among other regions, we observed significant group differences in amygdala activation, with patients showing less response particularly during approach to happy faces. Additionally, significant correlations of amygdala activation with psychopathology emerged, suggesting that more pronounced symptoms are accompanied by stronger decreases of amygdala activation. Hence, our results demonstrate that depressed patients show dysfunctional social approach and withdrawal behavior, which in turn may aggravate the disorder by negative social interactions contributing to isolation and reinforcing cognitive biases.
000016158 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000016158 650_2 $$2MeSH$$aAdult
000016158 650_2 $$2MeSH$$aBrain: physiopathology
000016158 650_2 $$2MeSH$$aBrain Mapping
000016158 650_2 $$2MeSH$$aDepressive Disorder, Major: physiopathology
000016158 650_2 $$2MeSH$$aFacial Expression
000016158 650_2 $$2MeSH$$aFemale
000016158 650_2 $$2MeSH$$aHumans
000016158 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000016158 650_2 $$2MeSH$$aMale
000016158 650_2 $$2MeSH$$aSocial Behavior
000016158 7001_ $$0P:(DE-HGF)0$$aSeidel, E.M.$$b1
000016158 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b2$$uFZJ
000016158 7001_ $$0P:(DE-HGF)0$$aKellermann, T.$$b3
000016158 7001_ $$0P:(DE-HGF)0$$aGur, R.C.$$b4
000016158 7001_ $$0P:(DE-HGF)0$$aSchneider, F.$$b5
000016158 7001_ $$0P:(DE-HGF)0$$aHabel, U.$$b6
000016158 773__ $$0PERI:(DE-600)2234411-1$$a10.1080/17470919.2011.579800$$gVol. 6$$q6$$tSocial neuroscience$$v6$$x1747-0919$$y2011
000016158 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203307
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000016158 9141_ $$y2011
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