TY  - JOUR
AU  - Derntl, B.
AU  - Seidel, E.M.
AU  - Eickhoff, S.B.
AU  - Kellermann, T.
AU  - Gur, R.C.
AU  - Schneider, F.
AU  - Habel, U.
TI  - Neural correlates of social approach and withdrawal in patients with major depression
JO  - Social neuroscience
VL  - 6
SN  - 1747-0919
CY  - New York [u.a.]
PB  - Psychology Press
M1  - PreJuSER-16158
PY  - 2011
N1  - Record converted from VDB: 12.11.2012
AB  - Successful human interaction is based on correct recognition, interpretation, and appropriate reaction to facial affect. In depression, social skill deficits are among the most restraining symptoms leading to social withdrawal, thereby aggravating social isolation and depressive affect. Dysfunctional approach and withdrawal tendencies to emotional stimuli have been documented, but the investigation of their neural underpinnings has received limited attention. We performed an fMRI study including 15 depressive patients and 15 matched, healthy controls. All subjects performed two tasks, an implicit joystick task as well as an explicit rating task, both using happy, neutral, and angry facial expressions. Behavioral data analysis indicated a significant group effect, with depressed patients showing more withdrawal than controls. Analysis of the functional data revealed significant group effects for both tasks. Among other regions, we observed significant group differences in amygdala activation, with patients showing less response particularly during approach to happy faces. Additionally, significant correlations of amygdala activation with psychopathology emerged, suggesting that more pronounced symptoms are accompanied by stronger decreases of amygdala activation. Hence, our results demonstrate that depressed patients show dysfunctional social approach and withdrawal behavior, which in turn may aggravate the disorder by negative social interactions contributing to isolation and reinforcing cognitive biases.
KW  - Adult
KW  - Brain: physiopathology
KW  - Brain Mapping
KW  - Depressive Disorder, Major: physiopathology
KW  - Facial Expression
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Social Behavior
LB  - PUB:(DE-HGF)16
C6  - pmid:21777105
C2  - pmc:PMC3203307
UR  - <Go to ISI:>//WOS:000299570500006
DO  - DOI:10.1080/17470919.2011.579800
UR  - https://juser.fz-juelich.de/record/16158
ER  -