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@ARTICLE{Derntl:16158,
      author       = {Derntl, B. and Seidel, E.M. and Eickhoff, S.B. and
                      Kellermann, T. and Gur, R.C. and Schneider, F. and Habel,
                      U.},
      title        = {{N}eural correlates of social approach and withdrawal in
                      patients with major depression},
      journal      = {Social neuroscience},
      volume       = {6},
      issn         = {1747-0919},
      address      = {New York [u.a.]},
      publisher    = {Psychology Press},
      reportid     = {PreJuSER-16158},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Successful human interaction is based on correct
                      recognition, interpretation, and appropriate reaction to
                      facial affect. In depression, social skill deficits are
                      among the most restraining symptoms leading to social
                      withdrawal, thereby aggravating social isolation and
                      depressive affect. Dysfunctional approach and withdrawal
                      tendencies to emotional stimuli have been documented, but
                      the investigation of their neural underpinnings has received
                      limited attention. We performed an fMRI study including 15
                      depressive patients and 15 matched, healthy controls. All
                      subjects performed two tasks, an implicit joystick task as
                      well as an explicit rating task, both using happy, neutral,
                      and angry facial expressions. Behavioral data analysis
                      indicated a significant group effect, with depressed
                      patients showing more withdrawal than controls. Analysis of
                      the functional data revealed significant group effects for
                      both tasks. Among other regions, we observed significant
                      group differences in amygdala activation, with patients
                      showing less response particularly during approach to happy
                      faces. Additionally, significant correlations of amygdala
                      activation with psychopathology emerged, suggesting that
                      more pronounced symptoms are accompanied by stronger
                      decreases of amygdala activation. Hence, our results
                      demonstrate that depressed patients show dysfunctional
                      social approach and withdrawal behavior, which in turn may
                      aggravate the disorder by negative social interactions
                      contributing to isolation and reinforcing cognitive biases.},
      keywords     = {Adult / Brain: physiopathology / Brain Mapping / Depressive
                      Disorder, Major: physiopathology / Facial Expression /
                      Female / Humans / Magnetic Resonance Imaging / Male / Social
                      Behavior},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21777105},
      pmc          = {pmc:PMC3203307},
      UT           = {WOS:000299570500006},
      doi          = {10.1080/17470919.2011.579800},
      url          = {https://juser.fz-juelich.de/record/16158},
}