Gast ::
| Hauptseite > Publikationsdatenbank > Interictal-like network activity and receptor expression in the epileptic human lateral amygdala > print |
| Hauptseite > Publikationsdatenbank > Interictal-like network activity and receptor expression in the epileptic human lateral amygdala > print |
| 001 | 16335 | ||
| 005 | 20210129210644.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:21893592 |
| 024 | 7 | _ | |2 DOI |a 10.1093/brain/awr202 |
| 024 | 7 | _ | |2 WOS |a WOS:000295681400013 |
| 037 | _ | _ | |a PreJuSER-16335 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Clinical Neurology |
| 084 | _ | _ | |2 WoS |a Neurosciences |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Graebenitz, S. |b 0 |
| 245 | _ | _ | |a Interictal-like network activity and receptor expression in the epileptic human lateral amygdala |
| 260 | _ | _ | |a Oxford |b Oxford Univ. Press |c 2011 |
| 300 | _ | _ | |a 2929 - 2947 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 935 |a Brain |v 134 |x 0006-8950 |y 10 |
| 500 | _ | _ | |a Deutsche Forschungsgemeinschaft (DFG; SFB-TR3, TP C3; to H. C. P. and E.J.S.); a research award (Max-Planck-Research Award 2007; to H. C. P.); the Helmholtz Alliances HelMA (Health in an Aging Society, to K.Z.); Systems Biology (to K.Z.). |
| 520 | _ | _ | |a While the amygdala is considered to play a critical role in temporal lobe epilepsy, conclusions on underlying pathophysiological mechanisms have been derived largely from experimental animal studies. Therefore, the present study aimed to characterize synaptic network interactions, focusing on spontaneous interictal-like activity, and the expression profile of transmitter receptors in the human lateral amygdala in relation to temporal lobe epilepsy. Electrophysiological recordings, obtained intra-operatively in vivo in patients with medically intractable temporal lobe epilepsy, revealed the existence of interictal activity in amygdala and hippocampus. For in vitro analyses, slices were prepared from surgically resected specimens, and sections from individual specimens were used for electrophysiological recordings, receptor autoradiographic analyses and histological visualization of major amygdaloid nuclei for verification of recording sites. In the lateral amygdala, interictal-like activity appeared as spontaneous slow rhythmic field potentials at an average frequency of 0.39 Hz, which occurred at different sites with various degrees of synchronization in 33.3% of the tested slices. Pharmacological blockade of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, but not N-methyl-D-aspartate receptors, abolished interictal-like activity, while the γ-aminobutyric acid A-type receptor antagonist bicuculline resulted in a dampening of activity, followed by highly synchronous patterns of slow rhythmic activity during washout. Receptor autoradiographic analysis revealed significantly higher α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, metabotropic glutamate type 2/3, muscarinic type 2 and adrenoceptor α(1) densities, whereas muscarinergic type 3 and serotonergic type 1A receptor densities were lower in the lateral amygdala from epileptic patients in comparison to autopsy controls. Concerning γ-aminobutyric acid A-type receptors, agonist binding was unaltered whereas antagonist binding sites were downregulated in the epileptic lateral amygdala, suggesting an altered high/low-affinity state ratio and concomitant reduced pool of total γ-aminobutyric acid A-type receptors. Together these data indicate an abnormal pattern of receptor densities and synaptic function in the lateral nucleus of the amygdala in epileptic patients, involving critical alterations in glutamate and γ-aminobutyric acid receptors, which may give rise to domains of spontaneous interictal discharges contributing to seizure activity in the amygdala. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK409 |2 G:(DE-HGF) |x 0 |c FUEK409 |a Funktion und Dysfunktion des Nervensystems (FUEK409) |
| 536 | _ | _ | |0 G:(DE-HGF)POF2-89571 |a 89571 - Connectivity and Activity (POF2-89571) |c POF2-89571 |f POF II T |x 1 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Adolescent |
| 650 | _ | 2 | |2 MeSH |a Adult |
| 650 | _ | 2 | |2 MeSH |a Aged |
| 650 | _ | 2 | |2 MeSH |a Amygdala: metabolism |
| 650 | _ | 2 | |2 MeSH |a Amygdala: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Child |
| 650 | _ | 2 | |2 MeSH |a Epilepsy: metabolism |
| 650 | _ | 2 | |2 MeSH |a Epilepsy: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Female |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Middle Aged |
| 650 | _ | 2 | |2 MeSH |a Nerve Net: metabolism |
| 650 | _ | 2 | |2 MeSH |a Nerve Net: physiopathology |
| 650 | _ | 2 | |2 MeSH |a Neurons: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptor, Muscarinic M2: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptor, Serotonin, 5-HT1A: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptors, AMPA: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptors, Adrenergic, alpha-1: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptors, Metabotropic Glutamate: metabolism |
| 650 | _ | 2 | |2 MeSH |a Synapses: metabolism |
| 650 | _ | 2 | |2 MeSH |a Synapses: physiology |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptor, Muscarinic M2 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, AMPA |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, Adrenergic, alpha-1 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, Metabotropic Glutamate |
| 650 | _ | 7 | |0 112692-38-3 |2 NLM Chemicals |a Receptor, Serotonin, 5-HT1A |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a lateral amygdala |
| 653 | 2 | 0 | |2 Author |a human temporal lobe epilepsy |
| 653 | 2 | 0 | |2 Author |a field potentials |
| 653 | 2 | 0 | |2 Author |a transmitter receptors |
| 653 | 2 | 0 | |2 Author |a intra-operative recording |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB20460 |a Kedo, O. |b 1 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Speckmann, E.J. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Gorji, A. |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Panneck, H. |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Hans, V. |b 5 |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB1208 |a Palomero-Gallagher, N. |b 6 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schleicher, A. |b 7 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131714 |a Zilles, K. |b 8 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Pape, H.C. |b 9 |
| 773 | _ | _ | |0 PERI:(DE-600)1474117-9 |a 10.1093/brain/awr202 |g Vol. 134, p. 2929 - 2947 |p 2929 - 2947 |q 134<2929 - 2947 |t Brain |v 134 |x 0006-8950 |y 2011 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1093/brain/awr202 |
| 909 | C | O | |o oai:juser.fz-juelich.de:16335 |p VDB |
| 913 | 2 | _ | |0 G:(DE-HGF)POF3-571 |1 G:(DE-HGF)POF3-570 |2 G:(DE-HGF)POF3-500 |a DE-HGF |b Key Technologies |l Decoding the Human Brain |v Connectivity and Activity |x 0 |
| 913 | 1 | _ | |0 G:(DE-HGF)POF2-89571 |a DE-HGF |v Connectivity and Activity |x 1 |4 G:(DE-HGF)POF |1 G:(DE-HGF)POF3-890 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-800 |b Programmungebundene Forschung |l ohne Programm |
| 914 | 1 | _ | |y 2011 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-2-20090406 |g INM |k INM-2 |l Molekulare Organisation des Gehirns |x 0 |
| 970 | _ | _ | |a VDB:(DE-Juel1)130181 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)INM-2-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|