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000016454 0247_ $$2DOI$$a10.1007/s00406-011-0249-8
000016454 0247_ $$2WOS$$aWOS:000296522100012
000016454 037__ $$aPreJuSER-16454
000016454 041__ $$aeng
000016454 082__ $$a610
000016454 084__ $$2WoS$$aClinical Neurology
000016454 084__ $$2WoS$$aPsychiatry
000016454 1001_ $$0P:(DE-HGF)0$$aNickl-Jockschat, T.$$b0
000016454 245__ $$aProgressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients
000016454 260__ $$aDarmstadt$$bSteinkopff$$c2011
000016454 300__ $$aS166-S171
000016454 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000016454 440_0 $$020301$$aEuropean Archives of Psychiatry and Clinical Neuroscience$$v261$$x0940-1334$$ySuppl. 2
000016454 500__ $$aThis supplement was not sponsored by outside commercial interests. It was funded by the German Association for Psychiatry and Psychotherapy (DGPPN).
000016454 520__ $$aSchizophrenia is a neuropsychiatric disorder entailing progressive psychotic, cognitive and affective symptoms. Several imaging studies identified brain structure abnormalities in schizophrenia patients, particularly in fronto-temporal regions and evidence for progressive anatomical changes. Here, we synthesised these findings by quantitative coordinate-based meta-analysis, assessing regions of consistently reported brain structure changes, their physiological functions and the correlation of their likelihood with disease duration. The meta-analysis revealed four significant clusters of convergent grey matter reduction, while one cluster indicated higher grey matter values in patients. A voxel-wise analysis revealed a correlation between grey matter reduction and disease duration in the left anterior insula. Functional characterisation revealed significant association with reward, affective processing and language functions. The current analysis allowed the identification of consistent morphometric changes across a large sample of studies in regions that are associated with neurophysiological functions that are altered as hallmarks of schizophrenia psychopathology. The observation that the location of presumably progressive pathology is functionally linked to language and emotion is well in line with increasing deficits in these domains with disease progression in schizophrenia.
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000016454 65320 $$2Author$$aSchizophrenia
000016454 65320 $$2Author$$aBrain structure
000016454 65320 $$2Author$$aAnatomical likelihood estimation
000016454 65320 $$2Author$$aDisease duration
000016454 65320 $$2Author$$aStructure-function relationship
000016454 65320 $$2Author$$aBrainMap
000016454 650_2 $$2MeSH$$aBrain: pathology
000016454 650_2 $$2MeSH$$aEmotions
000016454 650_2 $$2MeSH$$aHumans
000016454 650_2 $$2MeSH$$aLanguage
000016454 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000016454 650_2 $$2MeSH$$aSchizophrenia: pathology
000016454 650_2 $$2MeSH$$aSchizophrenic Psychology
000016454 650_2 $$2MeSH$$aSeverity of Illness Index
000016454 650_7 $$2WoSType$$aJ
000016454 7001_ $$0P:(DE-HGF)0$$aSchneider, F.$$b1
000016454 7001_ $$0P:(DE-HGF)0$$aPagel, A.D.$$b2
000016454 7001_ $$0P:(DE-HGF)0$$aLaird, A.R.$$b3
000016454 7001_ $$0P:(DE-HGF)0$$aFox, P.T.$$b4
000016454 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b5$$uFZJ
000016454 773__ $$0PERI:(DE-600)1459045-1$$a10.1007/s00406-011-0249-8$$gVol. 261, p. S166-S171$$pS166-S171$$q261<S166-S171$$tEuropean archives of psychiatry and clinical neuroscience$$v261$$x0940-1334$$y2011
000016454 8567_ $$uhttp://dx.doi.org/10.1007/s00406-011-0249-8
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000016454 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000016454 9141_ $$y2011
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