% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{NicklJockschat:16454,
      author       = {Nickl-Jockschat, T. and Schneider, F. and Pagel, A.D. and
                      Laird, A.R. and Fox, P.T. and Eickhoff, S.B.},
      title        = {{P}rogressive pathology is functionally linked to the
                      domains of language and emotion: meta-analysis of brain
                      structure changes in schizophrenia patients},
      journal      = {European archives of psychiatry and clinical neuroscience},
      volume       = {261},
      issn         = {0940-1334},
      address      = {Darmstadt},
      publisher    = {Steinkopff},
      reportid     = {PreJuSER-16454},
      pages        = {S166-S171},
      year         = {2011},
      note         = {This supplement was not sponsored by outside commercial
                      interests. It was funded by the German Association for
                      Psychiatry and Psychotherapy (DGPPN).},
      abstract     = {Schizophrenia is a neuropsychiatric disorder entailing
                      progressive psychotic, cognitive and affective symptoms.
                      Several imaging studies identified brain structure
                      abnormalities in schizophrenia patients, particularly in
                      fronto-temporal regions and evidence for progressive
                      anatomical changes. Here, we synthesised these findings by
                      quantitative coordinate-based meta-analysis, assessing
                      regions of consistently reported brain structure changes,
                      their physiological functions and the correlation of their
                      likelihood with disease duration. The meta-analysis revealed
                      four significant clusters of convergent grey matter
                      reduction, while one cluster indicated higher grey matter
                      values in patients. A voxel-wise analysis revealed a
                      correlation between grey matter reduction and disease
                      duration in the left anterior insula. Functional
                      characterisation revealed significant association with
                      reward, affective processing and language functions. The
                      current analysis allowed the identification of consistent
                      morphometric changes across a large sample of studies in
                      regions that are associated with neurophysiological
                      functions that are altered as hallmarks of schizophrenia
                      psychopathology. The observation that the location of
                      presumably progressive pathology is functionally linked to
                      language and emotion is well in line with increasing
                      deficits in these domains with disease progression in
                      schizophrenia.},
      keywords     = {Brain: pathology / Emotions / Humans / Language / Magnetic
                      Resonance Imaging / Schizophrenia: pathology / Schizophrenic
                      Psychology / Severity of Illness Index / J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Clinical Neurology / Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21909731},
      UT           = {WOS:000296522100012},
      doi          = {10.1007/s00406-011-0249-8},
      url          = {https://juser.fz-juelich.de/record/16454},
}