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@ARTICLE{Becker:16493,
      author       = {Becker, J.S. and Matusch, A. and Becker, J.Su. and Wu, B.
                      and Palm, C. and Becker, A.J. and Salber, S.},
      title        = {{M}ass spectrometric imaging ({MSI}) of metals using
                      advanced {B}rain{M}et techniques for biomedical research},
      journal      = {International journal of mass spectrometry},
      volume       = {307},
      issn         = {1387-3806},
      address      = {[S.l.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-16493},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Mass spectrometric imaging (MSI) is a young innovative
                      analytical technique and combines different fields of
                      advanced mass spectrometry and biomedical research with the
                      aim to provide maps of elements and molecules, complexes or
                      fragments. Especially essential metals such as zinc, copper,
                      iron and manganese play a functional role in signaling,
                      metabolism and homeostasis of the cell. Due to the high
                      degree of spatial organization of metals in biological
                      systems their distribution analysis is of key interest in
                      life sciences. We have developed analytical techniques
                      termed BrainMet using laser ablation inductively coupled
                      plasma mass spectrometry (LA-ICP-MS) imaging to measure the
                      distribution of trace metals in biological tissues for
                      biomedical research and feasibility studies-including
                      bioaccumulation and bioavailability studies, ecological risk
                      assessment and toxicity studies in humans and other
                      organisms. The analytical BrainMet techniques provide
                      quantitative images of metal distributions in brain tissue
                      slices which can be combined with other imaging modalities
                      such as photomicrography of native or processed tissue
                      (histochemistry, immunostaining) and autoradiography or with
                      in vivo techniques such as positron emission tomography or
                      magnetic resonance tomography.Prospective and instrumental
                      developments will be discussed concerning the development of
                      the metalloprotein microscopy using a laser microdissection
                      (LMD) apparatus for specific sample introduction into an
                      inductively coupled plasma mass spectrometer (LMD-ICP-MS) or
                      an application of the near field effect in LA-ICP-MS
                      (NF-LA-ICP-MS). These nano-scale mass spectrometric
                      techniques provide improved spatial resolution down to the
                      single cell level. (C) 2011 Elsevier B.V. All rights
                      reserved.},
      keywords     = {J (WoSType)},
      cin          = {ZCH / INM-2 / INM-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-4-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89574 - Theory, modelling and simulation (POF2-89574)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89574},
      shelfmark    = {Physics, Atomic, Molecular $\&$ Chemical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000295864100003},
      doi          = {10.1016/j.ijms.2011.01.015},
      url          = {https://juser.fz-juelich.de/record/16493},
}