% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Matusch:16497,
      author       = {Matusch, A. and Bauer, A. and Becker, J.S.},
      title        = {{E}lement imaging in formalin fixed slices of human
                      mesencephalon},
      journal      = {International journal of mass spectrometry},
      volume       = {307},
      issn         = {1387-3806},
      address      = {[S.l.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-16497},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The scarcity of native frozen pathological and healthy
                      human brain tissue is actually one of the major bottlenecks
                      concerning the investigation of neuropsychiatric diseases.
                      Therefore it is of some interest to make formalin fixed
                      tissue specimens accessible to mass spectrometric analytical
                      techniques. Laser ablation inductively coupled plasma mass
                      spectrometry (LA-ICP-MS) and matrix matched standards were
                      employed to generate quantitative element maps of human
                      mesencephalon slices that had been stored in formalin for
                      more than 10 years of a single subject. The characteristic
                      distribution patterns of Cu and Zn were completely blunted
                      but Fe was clearly enriched in the substantia nigra (SN) -
                      especially in the matrix of the pars compacta - and the
                      nucleus ruber (NR) at concentrations of 179 mu g g(-1), 231
                      mu g g(-1) and 187 mu g g(-1) (wet weight), respectively,
                      very similar to literature values obtained from homogenates
                      of fresh tissue. Mn and Ca congruently reflected the
                      distribution of melanised SN neurons. Interestingly, the
                      distribution of Pb was congruent to that of Fe reaching 0.8
                      mu g g(-1) in the SN, 1.1 mu g g(-1) in the matrix and 0.9
                      mu g g(-1) in the NR. Images of C and P reflected the gray
                      matter-white matter partition of the tissue. These results
                      suggest that a meaningful quantitative assessment of Fe, Mn
                      and Pb is possible in tissue samples which have previously
                      been stored in buffered formalin solution. (C) 2011 Elsevier
                      B.V. All rights reserved.},
      keywords     = {J (WoSType)},
      cin          = {ZCH / INM-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89574 - Theory, modelling and simulation (POF2-89574)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89574},
      shelfmark    = {Physics, Atomic, Molecular $\&$ Chemical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000295864100033},
      doi          = {10.1016/j.ijms.2011.03.006},
      url          = {https://juser.fz-juelich.de/record/16497},
}