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@ARTICLE{Sabir:16686,
      author       = {Sabir, T. and Schröder, G.F. and Toulmin, A. and McGlynn,
                      P. and Magennis, S.W.},
      title        = {{G}lobal {S}tructure of {F}orked {DNA} in {S}olution
                      {R}evealed by {H}igh-{R}esolution {S}ingle-{M}olecule
                      {FRET}},
      journal      = {Journal of the American Chemical Society},
      volume       = {133},
      issn         = {0002-7863},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-16686},
      pages        = {1188 - 1191},
      year         = {2011},
      note         = {We thank the BBSRC (BB/G00269X/1) for support and Claus
                      Seidel, Ralf Kuhnemuth, Suren Felekyan, Stefan Marawske,
                      Alessandro Valeri, and Evangelos Sisamakis for assistance in
                      developing our MFD setup. We thank Richard Henchman for
                      helpful discussions. S.W.M. acknowledges the award of an
                      EPSRC Advanced Research Fellowship (EP/D073154).},
      abstract     = {Branched DNA structures play critical roles in DNA
                      replication, repair, and recombination in addition to being
                      key building blocks for DNA nanotechnology. Here we combine
                      single-molecule multiparameter fluorescence detection and
                      molecular dynamics simulations to give a general approach to
                      global structure determination of branched DNA in solution.
                      We reveal an open, planar structure of a forked DNA molecule
                      with three duplex arms and demonstrate an ion-induced
                      conformational change. This structure will serve as a
                      benchmark for DNA-protein interaction studies.},
      keywords     = {Base Sequence / DNA: chemistry / Fluorescence Resonance
                      Energy Transfer / Molecular Dynamics Simulation / Nucleic
                      Acid Conformation / Solutions / Solutions (NLM Chemicals) /
                      DNA (NLM Chemicals) / J (WoSType)},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {Funktion und Dysfunktion des Nervensystems / BioSoft:
                      Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505},
      shelfmark    = {Chemistry, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21174398},
      UT           = {WOS:000287228500013},
      doi          = {10.1021/ja108626w},
      url          = {https://juser.fz-juelich.de/record/16686},
}