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@ARTICLE{Mhlhausen:1691,
      author       = {Mühlhausen, U. and Ermert, J. and Herth, M.M. and Coenen,
                      H. H.},
      title        = {{S}ynthesis, radiofluorination and first evaluation of
                      (+/-)-[18{F}]{MDL} 100907 as serotonin 5-{HT}2{A} receptor
                      antagonist for {PET}},
      journal      = {Journal of labelled compounds and radiopharmaceuticals},
      volume       = {52},
      issn         = {0362-4803},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {PreJuSER-1691},
      pages        = {6 - 12},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {In some psychiatric disorders 5-HT2A receptors play an
                      important role. In order to investigate those in vivo there
                      is an increasing interest in obtaining a metabolically
                      stable, subtype selective and high affinity radioligand for
                      receptor binding studies using positron emission tomography
                      (PET). Combining the excellent in vivo properties of
                      [C-11]MDL 100907 for PET imaging of 5-HT2A receptors and the
                      more suitable half-life of fluorine-18, MDL 100907 was
                      radiofluorinated in four steps using
                      1-(2-bromoethyl)-4-[F-18]fluorobenzene as a secondary
                      labelling precursor. The complex reaction required an
                      overall reaction time of 140 min and [+/-)-[F-18]MDL 100907
                      was obtained with a specific activity of at least 30 GBq/mu
                      mol (EOS) and an overall radiochemical yield of $1-2\%.$ In
                      order to verify its binding to 5-HT2A receptors, in vitro
                      rat brain autoradiography was conducted showing the typical
                      distribution of 5-HT2A receptors and a very low non-specific
                      binding of about $6\%$ in frontal cortex, using ketanserin
                      or spiperone for blocking. Thus, [F-18]MDL 100907 appears to
                      be a promising new 5-HT2A PET ligand.},
      keywords     = {J (WoSType)},
      cin          = {INB-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB807},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Biochemical Research Methods / Chemistry, Medicinal /
                      Chemistry, Analytical / Pharmacology $\&$ Pharmacy},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000263985000002},
      doi          = {10.1002/jlcr.1563},
      url          = {https://juser.fz-juelich.de/record/1691},
}