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000017017 0247_ $$2pmid$$apmid:20733533
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000017017 0247_ $$2DOI$$a10.5194/cp-7-1011-2011
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000017017 041__ $$aeng
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000017017 084__ $$2WoS$$aGeosciences, Multidisciplinary
000017017 084__ $$2WoS$$aMeteorology & Atmospheric Sciences
000017017 1001_ $$0P:(DE-Juel1)VDB1092$$aMoschen, R.$$b0$$uFZJ
000017017 245__ $$aTemperature variability at Dürres Maar, Germany, during the Migration Period and at High Medieval Times, inferred from stable carbon isotopes of Sphagnum cellulose
000017017 260__ $$aKatlenburg-Lindau$$bCopernicus Ges.$$c2011
000017017 300__ $$a1011 - 1026
000017017 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000017017 440_0 $$024821$$aClimate of the Past$$v7$$y3
000017017 500__ $$3POF3_Assignment on 2016-02-29
000017017 500__ $$aWe thank Georg Heumann, Thomas Litt, Jorn Parplies and Nils Riedel for assistance in the field. The help of Stefanie Wagner during core sampling is greatly acknowledged. Stable isotope measurements were carried out by Holger Wissel at the Institute of Bio- and Geosciences, Agrosphere. This work was supported by a grant of the Deutsche Forschungsgemeinschaft (German Research Foundation) to Robert Moschen (grant MO 1401/2-2).
000017017 520__ $$aTo assess the risk and identify risk factors of Hodgkin lymphoma (HL) in solid organ transplant recipients. Prior research has been limited by the rarity of HL and the requirement for extended follow-up after transplantation.Using data from the Scientific Registry of Transplant Recipients (SRTR), we conducted a retrospective cohort study of US solid organ transplant recipients (1997-2007). We estimated hazard ratios (HRs) for HL risk factors using proportional hazards regression. Standardized incidence ratios (SIRs) compared HL risk in the transplant cohort with the general population.The cohort included 283,190 transplant recipients (average follow-up: 3.7 years after transplantation). Based on 73 cases, HL risk factors included male gender (HR: 2.1, 95% CI: 1.2-3.7), young age (4.0, 2.3-6.8), and Epstein-Barr virus (EBV) seronegativity at the time of transplantation (3.1, 1.2-8.1). Among tumors with EBV status information, 79% were EBV positive, including all tumors in recipients who were initially seronegative. Overall, HL risk was higher than in the general population (SIR: 2.2) and increased monotonically over time after transplantation (SIR: 4.1 at 8-10 years posttransplant). Excess HL risk was especially high after heart and/or lung transplantation (SIR: 3.2).HL is a late complication of solid organ transplantation. The high HL risk in recipients who were young or EBV seronegative at the time of transplant and the fact that most HL tumors were EBV positive highlight the role of primary EBV infection and poor immune control of this virus. The occurrence of HL may rise with improved long-term survival in transplant recipients.
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000017017 588__ $$aDataset connected to Web of Science, Pubmed
000017017 650_2 $$2MeSH$$aAdolescent
000017017 650_2 $$2MeSH$$aAdult
000017017 650_2 $$2MeSH$$aChild
000017017 650_2 $$2MeSH$$aCohort Studies
000017017 650_2 $$2MeSH$$aFemale
000017017 650_2 $$2MeSH$$aFollow-Up Studies
000017017 650_2 $$2MeSH$$aHodgkin Disease: epidemiology
000017017 650_2 $$2MeSH$$aHumans
000017017 650_2 $$2MeSH$$aIncidence
000017017 650_2 $$2MeSH$$aMale
000017017 650_2 $$2MeSH$$aMiddle Aged
000017017 650_2 $$2MeSH$$aOrgan Transplantation: adverse effects
000017017 650_2 $$2MeSH$$aProportional Hazards Models
000017017 650_2 $$2MeSH$$aRetrospective Studies
000017017 650_2 $$2MeSH$$aRisk Factors
000017017 650_2 $$2MeSH$$aTime Factors
000017017 650_2 $$2MeSH$$aUnited States
000017017 650_7 $$2WoSType$$aJ
000017017 7001_ $$0P:(DE-HGF)0$$aKühl, N.$$b1
000017017 7001_ $$0P:(DE-HGF)0$$aPeters, S.$$b2
000017017 7001_ $$0P:(DE-HGF)0$$aVos, H.$$b3
000017017 7001_ $$0P:(DE-Juel1)129567$$aLücke, A.$$b4$$uFZJ
000017017 773__ $$0PERI:(DE-600)2217985-9$$a10.5194/cp-7-1011-2011$$gVol. 7, p. 1011 - 1026$$p1011 - 1026$$q7<1011 - 1026$$tClimate of the past$$v7$$x1814-9332$$y2011
000017017 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967618
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