TY  - JOUR
AU  - Moschen, R.
AU  - Kühl, N.
AU  - Peters, S.
AU  - Vos, H.
AU  - Lücke, A.
TI  - Temperature variability at Dürres Maar, Germany, during the Migration Period and at High Medieval Times, inferred from stable carbon isotopes of Sphagnum cellulose
JO  - Climate of the past
VL  - 7
SN  - 1814-9332
CY  - Katlenburg-Lindau
PB  - Copernicus Ges.
M1  - PreJuSER-17017
SP  - 1011 - 1026
PY  - 2011
N1  - We thank Georg Heumann, Thomas Litt, Jorn Parplies and Nils Riedel for assistance in the field. The help of Stefanie Wagner during core sampling is greatly acknowledged. Stable isotope measurements were carried out by Holger Wissel at the Institute of Bio- and Geosciences, Agrosphere. This work was supported by a grant of the Deutsche Forschungsgemeinschaft (German Research Foundation) to Robert Moschen (grant MO 1401/2-2).
AB  - To assess the risk and identify risk factors of Hodgkin lymphoma (HL) in solid organ transplant recipients. Prior research has been limited by the rarity of HL and the requirement for extended follow-up after transplantation.Using data from the Scientific Registry of Transplant Recipients (SRTR), we conducted a retrospective cohort study of US solid organ transplant recipients (1997-2007). We estimated hazard ratios (HRs) for HL risk factors using proportional hazards regression. Standardized incidence ratios (SIRs) compared HL risk in the transplant cohort with the general population.The cohort included 283,190 transplant recipients (average follow-up: 3.7 years after transplantation). Based on 73 cases, HL risk factors included male gender (HR: 2.1, 95% CI: 1.2-3.7), young age (4.0, 2.3-6.8), and Epstein-Barr virus (EBV) seronegativity at the time of transplantation (3.1, 1.2-8.1). Among tumors with EBV status information, 79% were EBV positive, including all tumors in recipients who were initially seronegative. Overall, HL risk was higher than in the general population (SIR: 2.2) and increased monotonically over time after transplantation (SIR: 4.1 at 8-10 years posttransplant). Excess HL risk was especially high after heart and/or lung transplantation (SIR: 3.2).HL is a late complication of solid organ transplantation. The high HL risk in recipients who were young or EBV seronegative at the time of transplant and the fact that most HL tumors were EBV positive highlight the role of primary EBV infection and poor immune control of this virus. The occurrence of HL may rise with improved long-term survival in transplant recipients.
KW  - Adolescent
KW  - Adult
KW  - Child
KW  - Cohort Studies
KW  - Female
KW  - Follow-Up Studies
KW  - Hodgkin Disease: epidemiology
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Organ Transplantation: adverse effects
KW  - Proportional Hazards Models
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Time Factors
KW  - United States
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20733533
C2  - pmc:PMC2967618
UR  - <Go to ISI:>//WOS:000295356800023
DO  - DOI:10.5194/cp-7-1011-2011
UR  - https://juser.fz-juelich.de/record/17017
ER  -