001     17017
005     20240709074004.0
024 7 _ |2 pmid
|a pmid:20733533
024 7 _ |2 pmc
|a pmc:PMC2967618
024 7 _ |2 DOI
|a 10.5194/cp-7-1011-2011
024 7 _ |2 WOS
|a WOS:000295356800023
037 _ _ |a PreJuSER-17017
041 _ _ |a eng
082 _ _ |a 550
084 _ _ |2 WoS
|a Geosciences, Multidisciplinary
084 _ _ |2 WoS
|a Meteorology & Atmospheric Sciences
100 1 _ |0 P:(DE-Juel1)VDB1092
|a Moschen, R.
|b 0
|u FZJ
245 _ _ |a Temperature variability at Dürres Maar, Germany, during the Migration Period and at High Medieval Times, inferred from stable carbon isotopes of Sphagnum cellulose
260 _ _ |a Katlenburg-Lindau
|b Copernicus Ges.
|c 2011
300 _ _ |a 1011 - 1026
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
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336 7 _ |a article
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440 _ 0 |0 24821
|a Climate of the Past
|v 7
|y 3
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a We thank Georg Heumann, Thomas Litt, Jorn Parplies and Nils Riedel for assistance in the field. The help of Stefanie Wagner during core sampling is greatly acknowledged. Stable isotope measurements were carried out by Holger Wissel at the Institute of Bio- and Geosciences, Agrosphere. This work was supported by a grant of the Deutsche Forschungsgemeinschaft (German Research Foundation) to Robert Moschen (grant MO 1401/2-2).
520 _ _ |a To assess the risk and identify risk factors of Hodgkin lymphoma (HL) in solid organ transplant recipients. Prior research has been limited by the rarity of HL and the requirement for extended follow-up after transplantation.Using data from the Scientific Registry of Transplant Recipients (SRTR), we conducted a retrospective cohort study of US solid organ transplant recipients (1997-2007). We estimated hazard ratios (HRs) for HL risk factors using proportional hazards regression. Standardized incidence ratios (SIRs) compared HL risk in the transplant cohort with the general population.The cohort included 283,190 transplant recipients (average follow-up: 3.7 years after transplantation). Based on 73 cases, HL risk factors included male gender (HR: 2.1, 95% CI: 1.2-3.7), young age (4.0, 2.3-6.8), and Epstein-Barr virus (EBV) seronegativity at the time of transplantation (3.1, 1.2-8.1). Among tumors with EBV status information, 79% were EBV positive, including all tumors in recipients who were initially seronegative. Overall, HL risk was higher than in the general population (SIR: 2.2) and increased monotonically over time after transplantation (SIR: 4.1 at 8-10 years posttransplant). Excess HL risk was especially high after heart and/or lung transplantation (SIR: 3.2).HL is a late complication of solid organ transplantation. The high HL risk in recipients who were young or EBV seronegative at the time of transplant and the fact that most HL tumors were EBV positive highlight the role of primary EBV infection and poor immune control of this virus. The occurrence of HL may rise with improved long-term survival in transplant recipients.
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|a Terrestrische Umwelt
|c P24
|x 0
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|a Atmosphäre und Klima
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|x 1
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|a Erneuerbare Energien
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|x 2
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Child
650 _ 2 |2 MeSH
|a Cohort Studies
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Follow-Up Studies
650 _ 2 |2 MeSH
|a Hodgkin Disease: epidemiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Incidence
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Organ Transplantation: adverse effects
650 _ 2 |2 MeSH
|a Proportional Hazards Models
650 _ 2 |2 MeSH
|a Retrospective Studies
650 _ 2 |2 MeSH
|a Risk Factors
650 _ 2 |2 MeSH
|a Time Factors
650 _ 2 |2 MeSH
|a United States
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-HGF)0
|a Kühl, N.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Peters, S.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Vos, H.
|b 3
700 1 _ |0 P:(DE-Juel1)129567
|a Lücke, A.
|b 4
|u FZJ
773 _ _ |0 PERI:(DE-600)2217985-9
|a 10.5194/cp-7-1011-2011
|g Vol. 7, p. 1011 - 1026
|p 1011 - 1026
|q 7<1011 - 1026
|t Climate of the past
|v 7
|x 1814-9332
|y 2011
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967618
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