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@ARTICLE{Rosar:17105,
      author       = {Rosar, C. and Kanonenberg, K. and Nanda, A.M. and
                      Mielewczik, M. and Bräutigam, A. and Novák, O. and
                      Strnade, M. and Walter, A. and Weber, A.P.M.},
      title        = {{T}he {L}eaf {R}eticulate {M}utant dov1 {I}s {I}mpaired in
                      the {F}irst {S}tep of {P}urine {M}etabolism},
      journal      = {Molecular plant},
      issn         = {1674-2052},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PreJuSER-17105},
      year         = {2012},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {A series of reticulated Arabidopsis thaliana mutants were
                      previously described. All mutants show a reticulate leaf
                      pattern, namely green veins on a pale leaf lamina. They have
                      an aberrant mesophyll structure but an intact layer of
                      bundle sheath cells around the veins. Here, we unravel the
                      function of the previously described reticulated EMS-mutant
                      dov1 (differential development of vascular associated cells
                      1). By positional cloning, we identified the mutated gene,
                      which encodes glutamine phosphoribosyl pyrophosphate
                      aminotransferase 2 (ATase2), an enzyme catalyzing the first
                      step of purine nucleotide biosynthesis. dov1 is allelic to
                      the previously characterized cia1-2 mutant that was isolated
                      in a screen for mutants with impaired chloroplast protein
                      import. We show that purine-derived total cytokinins are
                      lowered in dov1 and crosses with phytohormone reporter lines
                      revealed differential reporter activity patterns in dov1.
                      Metabolite profiling unraveled that amino acids that are
                      involved in purine biosynthesis are increased in dov1. This
                      study identified the molecular basis of an established
                      mutant line, which has the potential for further
                      investigation of the interaction between metabolism and leaf
                      development.},
      cin          = {IBG-2},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22532604},
      UT           = {WOS:000312573500010},
      doi          = {10.1093/mp/sss045},
      url          = {https://juser.fz-juelich.de/record/17105},
}