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@ARTICLE{Cornelius:171800,
author = {Cornelius, Jan F. and Stoffels, Gabriele and Filss,
Christian and Galldiks, Norbert and Slotty, Philipp and
Kamp, Marcel and el Khatib, Mustafa and Hänggi, Daniel and
Sabel, Michael and Felsberg, Jörg and Steiger, Hans Jakob
and Coenen, Heinrich Hubert and Shah, Nadim J. and Langen,
Karl-Josef},
title = {{U}ptake and tracer kinetics of
{O}-(2-18{F}-fluoroethyl)-l-tyrosine in meningiomas:
preliminary results.},
journal = {European journal of nuclear medicine and molecular imaging},
volume = {42},
number = {3},
issn = {1619-7089},
address = {Heidelberg [u.a.]},
publisher = {Springer-Verl.},
reportid = {FZJ-2014-05362},
pages = {459-467},
year = {2015},
abstract = {PurposeO-(2-[18F]Fluoroethyl)-l-tyrosine (18F-FET) is a
well-established PET tracer for the imaging of cerebral
gliomas, but little is known about 18F-FET uptake in
meningiomas. The aim of this study was to explore 18F-FET
kinetics and tumour-to-background contrast in meningiomas of
various histologies.MethodsA group of 24 patients with
suspected cerebral meningioma on MRI/CT had an additional
dynamic 18F-FET PET scan prior to surgery. Time–activity
curves (TAC) of 18F-FET uptake in the tumours and
tumour-to-brain ratios (TBR) for early (3 – 14 min after
injection) and late 18F-FET uptake (20 – 40 min after
injection) were analysed and compared with histological
subtypes and WHO grade. 18F-FET uptake in critical
structures in the skull base was also evaluated in terms of
tumour-to-tissue (T/Tis) ratio.ResultsTBR of 18F-FET uptake
in meningiomas was significantly higher in the early phase
than in the late phase (3.5 ± 0.8 vs. 2.2 ± 0.3; P
< 0.001). The difference in TBR between low-grade
meningiomas (WHO grade I, 18 patients) and high-grade
meningiomas (WHO grade II or III, 6 patients) was
significant in the late phase of 18F-FET uptake
(2.1 ± 0.2 vs. 2.5 ± 0.2, P = 0.003) while
there was no significant difference in the early phase. ROC
analysis showed that TBR of 18F-FET uptake in the late phase
had significant power to differentiate low-grade from
high-grade meningiomas (AUC 0.87 ± 0.18, sensitivity 83
$\%,$ specificity 83 $\%,$ optimal cut-off 2.3; P < 0.01).
Evaluation of TAC yielded three different curve patterns of
18F-FET PET uptake. Combination of TBR (cut-off value 2.3)
and TAC pattern slightly improved the differentiation of
high-grade from low-grade meningiomas (accuracy 92 $\%;$
P = 0.001). Analysis of background radioactivity in the
skull base indicated that 18F-FET uptake may be helpful in
distinguishing meningioma tissue in the late phase. T/Tis
ratios were >1.2 in all patients for the periorbita,
sphenoidal sinus, pituitary gland, tentorium, bone and
brain, in more than 90 $\%$ of patients for the mucosa and
dura, but in only 63 $\%$ of patients for the cavernous
sinus.Conclusion18F-FET PET may provide additional
information for noninvasive grading of meningiomas and
possibly for the discrimination of tumour in critical areas
of the skull base. A further evaluation of 18F-FET PET in
meningiomas appears to be justified.},
cin = {INM-3 / INM-4 / INM-5},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
I:(DE-Juel1)INM-5-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000349368700011},
doi = {10.1007/s00259-014-2934-0},
url = {https://juser.fz-juelich.de/record/171800},
}