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@ARTICLE{Cornelius:171800,
      author       = {Cornelius, Jan F. and Stoffels, Gabriele and Filss,
                      Christian and Galldiks, Norbert and Slotty, Philipp and
                      Kamp, Marcel and el Khatib, Mustafa and Hänggi, Daniel and
                      Sabel, Michael and Felsberg, Jörg and Steiger, Hans Jakob
                      and Coenen, Heinrich Hubert and Shah, Nadim J. and Langen,
                      Karl-Josef},
      title        = {{U}ptake and tracer kinetics of
                      {O}-(2-18{F}-fluoroethyl)-l-tyrosine in meningiomas:
                      preliminary results.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {42},
      number       = {3},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2014-05362},
      pages        = {459-467},
      year         = {2015},
      abstract     = {PurposeO-(2-[18F]Fluoroethyl)-l-tyrosine (18F-FET) is a
                      well-established PET tracer for the imaging of cerebral
                      gliomas, but little is known about 18F-FET uptake in
                      meningiomas. The aim of this study was to explore 18F-FET
                      kinetics and tumour-to-background contrast in meningiomas of
                      various histologies.MethodsA group of 24 patients with
                      suspected cerebral meningioma on MRI/CT had an additional
                      dynamic 18F-FET PET scan prior to surgery. Time–activity
                      curves (TAC) of 18F-FET uptake in the tumours and
                      tumour-to-brain ratios (TBR) for early (3 – 14 min after
                      injection) and late 18F-FET uptake (20 – 40 min after
                      injection) were analysed and compared with histological
                      subtypes and WHO grade. 18F-FET uptake in critical
                      structures in the skull base was also evaluated in terms of
                      tumour-to-tissue (T/Tis) ratio.ResultsTBR of 18F-FET uptake
                      in meningiomas was significantly higher in the early phase
                      than in the late phase (3.5 ± 0.8 vs. 2.2 ± 0.3; P
                      < 0.001). The difference in TBR between low-grade
                      meningiomas (WHO grade I, 18 patients) and high-grade
                      meningiomas (WHO grade II or III, 6 patients) was
                      significant in the late phase of 18F-FET uptake
                      (2.1 ± 0.2 vs. 2.5 ± 0.2, P = 0.003) while
                      there was no significant difference in the early phase. ROC
                      analysis showed that TBR of 18F-FET uptake in the late phase
                      had significant power to differentiate low-grade from
                      high-grade meningiomas (AUC 0.87 ± 0.18, sensitivity 83
                      $\%,$ specificity 83 $\%,$ optimal cut-off 2.3; P < 0.01).
                      Evaluation of TAC yielded three different curve patterns of
                      18F-FET PET uptake. Combination of TBR (cut-off value 2.3)
                      and TAC pattern slightly improved the differentiation of
                      high-grade from low-grade meningiomas (accuracy 92 $\%;$
                      P = 0.001). Analysis of background radioactivity in the
                      skull base indicated that 18F-FET uptake may be helpful in
                      distinguishing meningioma tissue in the late phase. T/Tis
                      ratios were >1.2 in all patients for the periorbita,
                      sphenoidal sinus, pituitary gland, tentorium, bone and
                      brain, in more than 90 $\%$ of patients for the mucosa and
                      dura, but in only 63 $\%$ of patients for the cavernous
                      sinus.Conclusion18F-FET PET may provide additional
                      information for noninvasive grading of meningiomas and
                      possibly for the discrimination of tumour in critical areas
                      of the skull base. A further evaluation of 18F-FET PET in
                      meningiomas appears to be justified.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000349368700011},
      doi          = {10.1007/s00259-014-2934-0},
      url          = {https://juser.fz-juelich.de/record/171800},
}