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000171842 1001_ $$0P:(DE-HGF)0$$aAccardo, Antonella$$b0
000171842 245__ $$aStructural insights on nanoparticles containing gadolinium complexes as potential theranostic
000171842 260__ $$aBerlin$$bSpringer$$c2014
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000171842 520__ $$aNanostructures are gaining interest in drug release applications. Amphiphilic molecules can give, in water solution, a variety of nanostructures as well as thermodynamically stable mesophases three-dimensional inverse cubic structures. These mesophases are attractive candidates for biomedical applications containing extensive water channel networks and could act as very efficient delivery systems of drugs or contrast agents. In order to discover, optimize, and develop these systems, we have performed a deep physicochemical characterization by dynamic light scattering and small-angle neutron scattering of nanoparticles of monoolein (MO) and Pluronic PF127, containing different amounts (1, 5, 10, and 20 %) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd). Nanoparticle size is found in the 70–400 nm range for all investigated systems; the morphology of the aggregates is driven by the main constituents MO/PF127 and is a mixture of multilayer vesicles and bicontinuous aggregates. Nanostructures are also able to encapsulate doxorubicin (drug-loading content between 70 and 90 % for the different systems) acting as a potential theranostic for simultaneous cancer therapy and MRI visualization.
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000171842 65027 $$0V:(DE-MLZ)SciArea-210$$2V:(DE-HGF)$$aSoft Condensed Matter$$x0
000171842 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x1
000171842 65017 $$0V:(DE-MLZ)GC-130-2016$$2V:(DE-HGF)$$aHealth and Life$$x2
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000171842 65017 $$0V:(DE-MLZ)GC-140$$2V:(DE-HGF)$$aSoft Matter, Macromolecules, Complex fluids, Biophysics$$x0
000171842 693__ $$0EXP:(DE-MLZ)KWS2-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS2-20140101$$6EXP:(DE-MLZ)NL3ao-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz$$eKWS-2: Small angle scattering diffractometer$$fNL3ao$$x0
000171842 693__ $$0EXP:(DE-MLZ)KWS3-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS3-20140101$$6EXP:(DE-MLZ)NL3auS-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz$$eKWS-3: Very small angle scattering diffractometer with focusing mirror$$fNL3auS$$x1
000171842 7001_ $$0P:(DE-HGF)0$$aRinghieri, Paola$$b1
000171842 7001_ $$0P:(DE-Juel1)145431$$aSzekely, Noemi$$b2
000171842 7001_ $$0P:(DE-Juel1)130893$$aPipich, Vitaliy$$b3
000171842 7001_ $$0P:(DE-HGF)0$$aLuchini, Alessandra$$b4
000171842 7001_ $$0P:(DE-HGF)0$$aPaduano, Luigi$$b5
000171842 7001_ $$0P:(DE-HGF)0$$aTesauro, Diego$$b6$$eCorresponding Author
000171842 773__ $$0PERI:(DE-600)1462029-7$$a10.1007/s00396-013-3159-7$$gVol. 292, no. 5, p. 1121 - 1127$$n5$$p1121 - 1127$$tColloid & polymer science$$v292$$x1435-1536$$y2014
000171842 8564_ $$uhttp://link.springer.com/article/10.1007/s00396-013-3159-7
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