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@ARTICLE{Accardo:171842,
      author       = {Accardo, Antonella and Ringhieri, Paola and Szekely, Noemi
                      and Pipich, Vitaliy and Luchini, Alessandra and Paduano,
                      Luigi and Tesauro, Diego},
      title        = {{S}tructural insights on nanoparticles containing
                      gadolinium complexes as potential theranostic},
      journal      = {Colloid $\&$ polymer science},
      volume       = {292},
      number       = {5},
      issn         = {1435-1536},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2014-05399},
      pages        = {1121 - 1127},
      year         = {2014},
      abstract     = {Nanostructures are gaining interest in drug release
                      applications. Amphiphilic molecules can give, in water
                      solution, a variety of nanostructures as well as
                      thermodynamically stable mesophases three-dimensional
                      inverse cubic structures. These mesophases are attractive
                      candidates for biomedical applications containing extensive
                      water channel networks and could act as very efficient
                      delivery systems of drugs or contrast agents. In order to
                      discover, optimize, and develop these systems, we have
                      performed a deep physicochemical characterization by dynamic
                      light scattering and small-angle neutron scattering of
                      nanoparticles of monoolein (MO) and Pluronic PF127,
                      containing different amounts (1, 5, 10, and 20 $\%)$ of the
                      synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd).
                      Nanoparticle size is found in the 70–400 nm range for all
                      investigated systems; the morphology of the aggregates is
                      driven by the main constituents MO/PF127 and is a mixture of
                      multilayer vesicles and bicontinuous aggregates.
                      Nanostructures are also able to encapsulate doxorubicin
                      (drug-loading content between 70 and 90 $\%$ for the
                      different systems) acting as a potential theranostic for
                      simultaneous cancer therapy and MRI visualization.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {54G - JCNS (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101 / EXP:(DE-MLZ)KWS3-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000335660200010},
      doi          = {10.1007/s00396-013-3159-7},
      url          = {https://juser.fz-juelich.de/record/171842},
}