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001     171842
005     20240619091121.0
024 7 _ |2 doi
|a 10.1007/s00396-013-3159-7
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|a 0023-2904
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|a 0303-402X
024 7 _ |2 ISSN
|a 0368-6590
024 7 _ |2 ISSN
|a 1435-1536
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037 _ _ |a FZJ-2014-05399
041 _ _ |a English
082 _ _ |a 540
100 1 _ |0 P:(DE-HGF)0
|a Accardo, Antonella
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245 _ _ |a Structural insights on nanoparticles containing gadolinium complexes as potential theranostic
260 _ _ |a Berlin
|b Springer
|c 2014
336 7 _ |a Journal Article
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520 _ _ |a Nanostructures are gaining interest in drug release applications. Amphiphilic molecules can give, in water solution, a variety of nanostructures as well as thermodynamically stable mesophases three-dimensional inverse cubic structures. These mesophases are attractive candidates for biomedical applications containing extensive water channel networks and could act as very efficient delivery systems of drugs or contrast agents. In order to discover, optimize, and develop these systems, we have performed a deep physicochemical characterization by dynamic light scattering and small-angle neutron scattering of nanoparticles of monoolein (MO) and Pluronic PF127, containing different amounts (1, 5, 10, and 20 %) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd). Nanoparticle size is found in the 70–400 nm range for all investigated systems; the morphology of the aggregates is driven by the main constituents MO/PF127 and is a mixture of multilayer vesicles and bicontinuous aggregates. Nanostructures are also able to encapsulate doxorubicin (drug-loading content between 70 and 90 % for the different systems) acting as a potential theranostic for simultaneous cancer therapy and MRI visualization.
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|a Forschungs-Neutronenquelle Heinz Maier-Leibnitz
|e KWS-2: Small angle scattering diffractometer
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700 1 _ |0 P:(DE-HGF)0
|a Ringhieri, Paola
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|a Szekely, Noemi
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|a Pipich, Vitaliy
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700 1 _ |0 P:(DE-HGF)0
|a Luchini, Alessandra
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700 1 _ |0 P:(DE-HGF)0
|a Paduano, Luigi
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700 1 _ |0 P:(DE-HGF)0
|a Tesauro, Diego
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|e Corresponding Author
773 _ _ |0 PERI:(DE-600)1462029-7
|a 10.1007/s00396-013-3159-7
|g Vol. 292, no. 5, p. 1121 - 1127
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|t Colloid & polymer science
|v 292
|x 1435-1536
|y 2014
856 4 _ |u http://link.springer.com/article/10.1007/s00396-013-3159-7
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