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000171844 1001_ $$0P:(DE-HGF)0$$aMcDaniel, Jonathan R.$$b0$$eCorresponding Author
000171844 245__ $$aNoncanonical Self-Assembly of Highly Asymmetric Genetically Encoded Polypeptide Amphiphiles into Cylindrical Micelles
000171844 260__ $$aWashington, DC$$bACS Publ.$$c2014
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000171844 520__ $$aElastin-like polypeptides (ELPs) are a class of biopolymers consisting of the pentameric repeat (VPGαG)n based on the sequence of mammalian tropoelastin that display a thermally induced soluble-to-insoluble phase transition in aqueous solution. We have discovered a remarkably simple approach to driving the spontaneous self-assembly of high molecular weight ELPs into nanostructures by genetically fusing a short 1.5 kDa (XGy)z assembly domain to one end of the ELP. Classical theories of self-assembly based on the geometric mass balance of hydrophilic and hydrophobic block copolymers suggest that these highly asymmetric polypeptides should form spherical micelles. Surprisingly, when sufficiently hydrophobic amino acids (X) are presented in a periodic sequence such as (FGG)8 or (YG)8, these highly asymmetric polypeptides self-assemble into cylindrical micelles whose length can be tuned by the sequence of the morphogenic tag. These nanostructures were characterized by light scattering, tunable resistive pulse sensing, fluorescence spectrophotometry, and thermal turbidimetry, as well as by cryogenic transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). These short assembly domains provide a facile strategy to control the size, shape, and stability of stimuli responsive polypeptide nanostructures.
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000171844 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x2
000171844 65017 $$0V:(DE-MLZ)GC-150-1$$2V:(DE-HGF)$$aKey Technologies$$x1
000171844 65017 $$0V:(DE-MLZ)GC-140$$2V:(DE-HGF)$$aSoft Matter, Macromolecules, Complex fluids, Biophysics$$x0
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000171844 7001_ $$0P:(DE-HGF)0$$aWeitzhandler, Isaac$$b1
000171844 7001_ $$0P:(DE-HGF)0$$aPrevost, Sylvain$$b2
000171844 7001_ $$0P:(DE-HGF)0$$aVargo, Kevin B.$$b3
000171844 7001_ $$0P:(DE-Juel1)130507$$aAppavou, Marie-Sousai$$b4$$ufzj
000171844 7001_ $$0P:(DE-HGF)0$$aHammer, Daniel A.$$b5
000171844 7001_ $$0P:(DE-HGF)0$$aGradzielski, Michael$$b6
000171844 7001_ $$0P:(DE-HGF)0$$aChilkoti, Ashutosh$$b7
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