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000172411 1001_ $$0P:(DE-HGF)0$$aDiehl-Schmid, Janine$$b0$$eCorresponding Author
000172411 245__ $$aImaging Frontotemporal Lobar Degeneration
000172411 260__ $$aPhiladelphia, Pa.$$bCurrent Science Inc.$$c2014
000172411 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1430224148_26977
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000172411 520__ $$aThe term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer’s disease in patients below the age of 65. The 3 major clinical syndromes associated with FTLD include behavioral variant frontotemporal dementia, semantic and nonfluent variants of primary progressive aphasia. The more recently introduced term logopenic variant appears to represent an atypical form of Alzheimer’s disease in the majority of cases. The neuropathology underlying these clinical syndromes is very heterogeneous and does not correlate well with the clinical phenotype. This causes great difficulties in early and reliable diagnosis and treatment of FTLD. However, significant advances have been made in recent years via the application of magnetic resonance imaging and positron emission tomography imaging methods as biomarkers. The current review aims to provide a synopsis on the value of magnetic resonance imaging-based and molecular imaging procedures in FTLD.
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000172411 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür$$b1$$ufzj
000172411 7001_ $$0P:(DE-HGF)0$$aKuhn, Jens$$b2
000172411 7001_ $$0P:(DE-HGF)0$$aGruppe, Traugott$$b3
000172411 7001_ $$0P:(DE-HGF)0$$aDrzezga, Alexander$$b4
000172411 773__ $$0PERI:(DE-600)2094171-7$$a10.1007/s11910-014-0489-x$$gVol. 14, no. 10, p. 489$$n10$$pArticle 489, p. 1 - 11$$tCurrent neurology and neuroscience reports$$v14$$x1534-6293$$y2014
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