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@ARTICLE{DiehlSchmid:172411,
      author       = {Diehl-Schmid, Janine and Onur, Özgür and Kuhn, Jens and
                      Gruppe, Traugott and Drzezga, Alexander},
      title        = {{I}maging {F}rontotemporal {L}obar {D}egeneration},
      journal      = {Current neurology and neuroscience reports},
      volume       = {14},
      number       = {10},
      issn         = {1534-6293},
      address      = {Philadelphia, Pa.},
      publisher    = {Current Science Inc.},
      reportid     = {FZJ-2014-05889},
      pages        = {Article 489, p. 1 - 11},
      year         = {2014},
      abstract     = {The term frontotemporal lobar degeneration (FTLD) refers to
                      a group of neurodegenerative disorders that target the
                      frontal and temporal lobes. It accounts for approximately 10
                      $\%$ of pathologically confirmed dementias but has been
                      demonstrated to be as prevalent as Alzheimer’s disease in
                      patients below the age of 65. The 3 major clinical syndromes
                      associated with FTLD include behavioral variant
                      frontotemporal dementia, semantic and nonfluent variants of
                      primary progressive aphasia. The more recently introduced
                      term logopenic variant appears to represent an atypical form
                      of Alzheimer’s disease in the majority of cases. The
                      neuropathology underlying these clinical syndromes is very
                      heterogeneous and does not correlate well with the clinical
                      phenotype. This causes great difficulties in early and
                      reliable diagnosis and treatment of FTLD. However,
                      significant advances have been made in recent years via the
                      application of magnetic resonance imaging and positron
                      emission tomography imaging methods as biomarkers. The
                      current review aims to provide a synopsis on the value of
                      magnetic resonance imaging-based and molecular imaging
                      procedures in FTLD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000342073900006},
      pubmed       = {pmid:25171901},
      doi          = {10.1007/s11910-014-0489-x},
      url          = {https://juser.fz-juelich.de/record/172411},
}