%0 Journal Article
%A Tiruttani Subhramanyam, Udaya Kumar
%A Kubicek, Jan
%A Eidhoff, Ulf B.
%A Labahn, Jörg
%T Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR)
%J Acta crystallographica / F
%V 70
%@ 1744-3091
%C Oxford [u.a.]
%I Blackwell
%M FZJ-2014-05896
%P 1224 - 1227
%D 2014
%X Prostate apoptosis response-4 protein is an intrinsically disordered pro-apoptotic protein with tumour suppressor function. Par-4 is known for its selective induction of apoptosis in cancer cells only and its ability to interact with various apoptotic proteins via its C-terminus. Par-4, with its unique function and various interacting partners, has gained importance as a potential target for cancer therapy. The C-terminus of the rat homologue of Par-4 was crystallized and a 3.7 Å resolution X-ray diffraction data set was collected. Preliminary data analysis shows the space group to be P41212. The unit-cell parameters are a = b = 115.351, c = 123.663 Å, α = β = γ = 90°.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000341818600019
%$ pmid:25195896
%R 10.1107/S2053230X14014691
%U https://juser.fz-juelich.de/record/172418