TY  - JOUR
AU  - Tiruttani Subhramanyam, Udaya Kumar
AU  - Kubicek, Jan
AU  - Eidhoff, Ulf B.
AU  - Labahn, Jörg
TI  - Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR)
JO  - Acta crystallographica / F
VL  - 70
SN  - 1744-3091
CY  - Oxford [u.a.]
PB  - Blackwell
M1  - FZJ-2014-05896
SP  - 1224 - 1227
PY  - 2014
AB  - Prostate apoptosis response-4 protein is an intrinsically disordered pro-apoptotic protein with tumour suppressor function. Par-4 is known for its selective induction of apoptosis in cancer cells only and its ability to interact with various apoptotic proteins via its C-terminus. Par-4, with its unique function and various interacting partners, has gained importance as a potential target for cancer therapy. The C-terminus of the rat homologue of Par-4 was crystallized and a 3.7 Å resolution X-ray diffraction data set was collected. Preliminary data analysis shows the space group to be P41212. The unit-cell parameters are a = b = 115.351, c = 123.663 Å, α = β = γ = 90°.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000341818600019
C6  - pmid:25195896
DO  - DOI:10.1107/S2053230X14014691
UR  - https://juser.fz-juelich.de/record/172418
ER  -