TY  - JOUR
AU  - Koy, Anne
AU  - Pauls, K. Amande M.
AU  - Flossdorf, Pia
AU  - Becker, Johannes
AU  - Schönau, Eckhard
AU  - Maarouf, Mohammad
AU  - Liebig, Thomas
AU  - Fricke, Oliver
AU  - Fink, Gereon R.
AU  - Timmermann, Lars
TI  - Young Adults with Dyskinetic Cerebral Palsy Improve Subjectively on Pallidal Stimulation, but not in Formal Dystonia, Gait, Speech and Swallowing Testing
JO  - European neurology
VL  - 72
IS  - 5-6
SN  - 1421-9913
CY  - Basel
PB  - Karger
M1  - FZJ-2014-06142
SP  - 340 - 348
PY  - 2014
AB  - Background: Pharmacological treatment of dyskinetic cerebral palsy (CP) is often ineffective. Data about outcome of deep brain stimulation (DBS) in these patients remains scarce. Methods: Eight patients with dyskinetic CP and DBS of the Globus Pallidus internus were investigated. Using pre- and postoperative videos the severity of dystonia and changes thereof during standardized settings (‘on') and after the stimulator had been switched off (‘off') were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Furthermore, subjective impression (SI) of the extent of postoperative change as well as gait (Leonardo Mechanograph® Gangway), speech (Frenchay Dysarthria) and swallowing performances (fiberoptic laryngoscopy) were assessed during ‘on' and ‘off'. Results: When comparing pre- and postoperative as well as ‘on' and ‘off', the BFMDRS and most of the gait, speech, and swallowing parameters did not differ significantly. In contrast, patients reported significant improvement of their SI postoperatively (3.1 on a 10-point-scale). Conclusion: Data show that our CP-patients did not benefit from GPi-DBS when tested formally for dystonia, gait, speech and swallowing. In stark contrast, these patients reported significant subjective improvement. Taken together, and in light of current unsatisfactory medical treatment options, our data suggest that further assessment of the effects of GPi-DBS in dyskinetic CP is warranted.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000345658900015
C6  - pmid:25322688
DO  - DOI:10.1159/000360984
UR  - https://juser.fz-juelich.de/record/172690
ER  -