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@ARTICLE{Koy:172690,
      author       = {Koy, Anne and Pauls, K. Amande M. and Flossdorf, Pia and
                      Becker, Johannes and Schönau, Eckhard and Maarouf, Mohammad
                      and Liebig, Thomas and Fricke, Oliver and Fink, Gereon R.
                      and Timmermann, Lars},
      title        = {{Y}oung {A}dults with {D}yskinetic {C}erebral {P}alsy
                      {I}mprove {S}ubjectively on {P}allidal {S}timulation, but
                      not in {F}ormal {D}ystonia, {G}ait, {S}peech and
                      {S}wallowing {T}esting},
      journal      = {European neurology},
      volume       = {72},
      number       = {5-6},
      issn         = {1421-9913},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {FZJ-2014-06142},
      pages        = {340 - 348},
      year         = {2014},
      abstract     = {Background: Pharmacological treatment of dyskinetic
                      cerebral palsy (CP) is often ineffective. Data about outcome
                      of deep brain stimulation (DBS) in these patients remains
                      scarce. Methods: Eight patients with dyskinetic CP and DBS
                      of the Globus Pallidus internus were investigated. Using
                      pre- and postoperative videos the severity of dystonia and
                      changes thereof during standardized settings (‘on') and
                      after the stimulator had been switched off (‘off') were
                      assessed using the Burke-Fahn-Marsden Dystonia Rating Scale
                      (BFMDRS). Furthermore, subjective impression (SI) of the
                      extent of postoperative change as well as gait (Leonardo
                      Mechanograph® Gangway), speech (Frenchay Dysarthria) and
                      swallowing performances (fiberoptic laryngoscopy) were
                      assessed during ‘on' and ‘off'. Results: When comparing
                      pre- and postoperative as well as ‘on' and ‘off', the
                      BFMDRS and most of the gait, speech, and swallowing
                      parameters did not differ significantly. In contrast,
                      patients reported significant improvement of their SI
                      postoperatively (3.1 on a 10-point-scale). Conclusion: Data
                      show that our CP-patients did not benefit from GPi-DBS when
                      tested formally for dystonia, gait, speech and swallowing.
                      In stark contrast, these patients reported significant
                      subjective improvement. Taken together, and in light of
                      current unsatisfactory medical treatment options, our data
                      suggest that further assessment of the effects of GPi-DBS in
                      dyskinetic CP is warranted.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000345658900015},
      pubmed       = {pmid:25322688},
      doi          = {10.1159/000360984},
      url          = {https://juser.fz-juelich.de/record/172690},
}