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@ARTICLE{Kohls:172849,
      author       = {Kohls, G. and Thönessen, H. and Bartleyc, G. K. and
                      Grossheinrich, N. and Fink, G. R. and Herpertz-Dahlmanne, B.
                      and Konrad, K.},
      title        = {{D}ifferentiating neural reward responsiveness in autism
                      versus {ADHD}.},
      journal      = {Developmental cognitive neuroscience},
      volume       = {10},
      issn         = {1878-9293},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2014-06283},
      pages        = {104 - 116},
      year         = {2014},
      abstract     = {Although attention deficit hyperactivity disorders (ADHD)
                      and autism spectrum disorders (ASD) share certain
                      neurocognitive characteristics, it has been hypothesized to
                      differentiate the two disorders based on their brain's
                      reward responsiveness to either social or monetary reward.
                      Thus, the present fMRI study investigated neural activation
                      in response to both reward types in age and IQ-matched boys
                      with ADHD versus ASD relative to typically controls (TDC). A
                      significant group by reward type interaction effect emerged
                      in the ventral striatum with greater activation to monetary
                      versus social reward only in TDC, whereas subjects with ADHD
                      responded equally strong to both reward types, and subjects
                      with ASD showed low striatal reactivity across both reward
                      conditions. Moreover, disorder-specific neural abnormalities
                      were revealed, including medial prefrontal hyperactivation
                      in response to social reward in ADHD versus ventral striatal
                      hypoactivation in response to monetary reward in ASD. Shared
                      dysfunction was characterized by fronto-striato-parietal
                      hypoactivation in both clinical groups when money was at
                      stake. Interestingly, lower neural activation within
                      parietal circuitry was associated with higher autistic
                      traits across the entire study sample. In sum, the present
                      findings concur with the assumption that both ASD and ADHD
                      display distinct and shared neural dysfunction in response
                      to reward.},
      cin          = {INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000344944200009},
      pubmed       = {pmid:25190643},
      doi          = {10.1016/j.dcn.2014.08.003},
      url          = {https://juser.fz-juelich.de/record/172849},
}