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@ARTICLE{Petrelli:173141,
author = {Petrelli, A. and Kaesberg, S. and Barbe, M. T. and
Timermann, L. and Fink, Gereon Rudolf and Kessler, J. and
Kalbe, E.},
title = {{E}ffects of cognitive training in {P}arkinson's disease:
{A} randomized controlled trial},
journal = {Parkinsonism $\&$ related disorders},
volume = {20},
issn = {1353-8020},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2014-06554},
pages = {1196-1202},
year = {2014},
abstract = {BackgroundIn Parkinson's Disease (PD), cognitive
dysfunctions which can reduce patients' quality of life
occur frequently. Data on non-pharmacological intervention
effects on cognitive functions in patients with PD are rare.
The aim of this study was to examine the effects of
different cognitive group trainings (structured vs.
unstructured) on cognition, depression, and quality of life
in non-demented PD patients.MethodsIn this randomized
controlled trial, 65 non-demented patients with PD according
to UK Brain Bank criteria (Hoehn $\&$ Yahr I-III) were
allocated to one of two cognitive multi-component treatments
(“NEUROvitalis”, a structured training, or the
unstructured training “Mentally fit” with randomly
assembled cognitive tasks, each including 12 group-sessions
à 90 min over 6 weeks) or a waiting list control group
(CG). A neuropsychological test battery was performed before
and after the training.ResultsCompared to the CG, patients
from the “NEUROvitalis” group improved in short-term
memory (word list learning “Memo”: p < .01) and working
memory (digit span reverse from “DemTect”: p < .05),
whereas depression scores where reduced in the “Mentally
fit” group (Beck Depression Inventory-II: p < .05). The
“NEUROvitalis” group improved significantly more in
working memory than the “Mentally fit” group (DemTect: p
< .05).DiscussionCognitive and affective functions can be
improved by cognitive trainings in PD patients. Specific
effects (e.g. on memory and working memory versus
depression) seem to be dependent on the type of training.
Further research is needed to define long-term effects and
the efficacy in PD patients with different extent of
cognitive and neuropsychiatric symptoms.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {333 - Pathophysiological Mechanisms of Neurological and
Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
Plasticity (POF2-89572)},
pid = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000345483000017},
pubmed = {pmid:25242806},
doi = {10.1016/j.parkreldis.2014.08.023},
url = {https://juser.fz-juelich.de/record/173141},
}