TY  - JOUR
AU  - Steinberg, S.
AU  - et, al.
TI  - Common variants at VRK2 and TCF4 conferring risk of schizophrenia
JO  - Human molecular genetics
VL  - 20
SN  - 0964-6906
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-17360
SP  - 4076 - 4081
PY  - 2011
N1  - This work was supported by the European Union [grant numbers LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene), HEALTH-F2-2009-223423 (Project PsychCNVs)]; the National Genome Research Network of the German Federal Ministry of Education and Research (BMBF) [grant numbers 01GS08144 (MooDS-Net), 01GS08147 (NGFNplus)]; the National Institute of Mental Health [R01 MH078075, and N01 MH900001, MH074027 to the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project]; the Centre of Excellence for Complex Disease Genetics of the Academy of Finland (grant numbers 213506, 129680); the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki; the Stanley Medical Research Institute; the Danish Council for Strategic Research (grant number 2101-07-0059); H. Lundbeck A/S; the Research Council of Norway (grant number 163070/V50); the South-East Norway Health Authority (grant number 2004-123); the Medical Research Council; Ministerio de Sanidad y Consumo, Spain (grant number PI081522 to J.C.); Xunta de Galicia (grant number 08CSA005208PR to A.C.); the Swedish Research Council; the Wellcome Trust (grant number 083948/Z/07/Z as part of the Wellcome Trust Case Control Consortium 2); the Max Planck Society and Eli Lilly and Company (genotyping for CATIE and part of the TOP sample).
AB  - Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)).
KW  - Alleles
KW  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: genetics
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Genotype
KW  - Humans
KW  - Polymorphism, Single Nucleotide
KW  - Protein-Serine-Threonine Kinases: genetics
KW  - Risk
KW  - Schizophrenia: genetics
KW  - Transcription Factors: genetics
KW  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (NLM Chemicals)
KW  - TCF4 protein, human (NLM Chemicals)
KW  - Transcription Factors (NLM Chemicals)
KW  - Protein-Serine-Threonine Kinases (NLM Chemicals)
KW  - VRK2 protein, human (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21791550
C2  - pmc:PMC3298077
UR  - <Go to ISI:>//WOS:000295171200017
DO  - DOI:10.1093/hmg/ddr325
UR  - https://juser.fz-juelich.de/record/17360
ER  -