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@ARTICLE{Steinberg:17360,
      author       = {Steinberg, S. and et, al.},
      title        = {{C}ommon variants at {VRK}2 and {TCF}4 conferring risk of
                      schizophrenia},
      journal      = {Human molecular genetics},
      volume       = {20},
      issn         = {0964-6906},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PreJuSER-17360},
      pages        = {4076 - 4081},
      year         = {2011},
      note         = {This work was supported by the European Union [grant
                      numbers LSHM-CT-2006-037761 (Project SGENE),
                      PIAP-GA-2008-218251 (Project PsychGene),
                      HEALTH-F2-2009-223423 (Project PsychCNVs)]; the National
                      Genome Research Network of the German Federal Ministry of
                      Education and Research (BMBF) [grant numbers 01GS08144
                      (MooDS-Net), 01GS08147 (NGFNplus)]; the National Institute
                      of Mental Health [R01 MH078075, and N01 MH900001, MH074027
                      to the Clinical Antipsychotic Trials of Intervention
                      Effectiveness (CATIE) project]; the Centre of Excellence for
                      Complex Disease Genetics of the Academy of Finland (grant
                      numbers 213506, 129680); the Biocentrum Helsinki Foundation
                      and Research Program for Molecular Medicine, Faculty of
                      Medicine, University of Helsinki; the Stanley Medical
                      Research Institute; the Danish Council for Strategic
                      Research (grant number 2101-07-0059); H. Lundbeck A/S; the
                      Research Council of Norway (grant number 163070/V50); the
                      South-East Norway Health Authority (grant number 2004-123);
                      the Medical Research Council; Ministerio de Sanidad y
                      Consumo, Spain (grant number PI081522 to J.C.); Xunta de
                      Galicia (grant number 08CSA005208PR to A.C.); the Swedish
                      Research Council; the Wellcome Trust (grant number
                      083948/Z/07/Z as part of the Wellcome Trust Case Control
                      Consortium 2); the Max Planck Society and Eli Lilly and
                      Company (genotyping for CATIE and part of the TOP sample).},
      abstract     = {Common sequence variants have recently joined rare
                      structural polymorphisms as genetic factors with strong
                      evidence for association with schizophrenia. Here we extend
                      our previous genome-wide association study and meta-analysis
                      (totalling 7 946 cases and 19 036 controls) by examining an
                      expanded set of variants using an enlarged follow-up sample
                      (up to 10 260 cases and 23 500 controls). In addition to
                      previously reported alleles in the major histocompatibility
                      complex region, near neurogranin (NRGN) and in an intron of
                      transcription factor 4 (TCF4), we find two novel variants
                      showing genome-wide significant association: rs2312147[C],
                      upstream of vaccinia-related kinase 2 (VRK2) [odds ratio
                      (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between
                      coiled-coiled domain containing 68 (CCDC68) and TCF4, about
                      400 kb from the previously described risk allele, but not
                      accounted for by its association (OR = 1.09, P = 7.8 ×
                      10(-9)).},
      keywords     = {Alleles / Basic Helix-Loop-Helix Leucine Zipper
                      Transcription Factors: genetics / Genetic Predisposition to
                      Disease / Genome-Wide Association Study / Genotype / Humans
                      / Polymorphism, Single Nucleotide / Protein-Serine-Threonine
                      Kinases: genetics / Risk / Schizophrenia: genetics /
                      Transcription Factors: genetics / Basic Helix-Loop-Helix
                      Leucine Zipper Transcription Factors (NLM Chemicals) / TCF4
                      protein, human (NLM Chemicals) / Transcription Factors (NLM
                      Chemicals) / Protein-Serine-Threonine Kinases (NLM
                      Chemicals) / VRK2 protein, human (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems / PSYCHGENE -
                      Copy Number Variation and Endophenotypes in Psychiatric
                      Disorders (218251) / PSYCHCNVS - Copy number variations
                      conferring risk of psychiatric disorders in children
                      (223423)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(EU-Grant)218251 /
                      G:(EU-Grant)223423},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Genetics $\&$
                      Heredity},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21791550},
      pmc          = {pmc:PMC3298077},
      UT           = {WOS:000295171200017},
      doi          = {10.1093/hmg/ddr325},
      url          = {https://juser.fz-juelich.de/record/17360},
}