Hauptseite > Publikationsdatenbank > Common variants at VRK2 and TCF4 conferring risk of schizophrenia > print

001     17360
005     20190625111329.0
024 7 _ |2 pmid
|a pmid:21791550
024 7 _ |2 pmc
|a pmc:PMC3298077
024 7 _ |2 DOI
|a 10.1093/hmg/ddr325
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|a WOS:000295171200017
024 7 _ |a altmetric:200331
|2 altmetric
037 _ _ |a PreJuSER-17360
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Genetics & Heredity
100 1 _ |0 P:(DE-HGF)0
|a Steinberg, S.
|b 0
245 _ _ |a Common variants at VRK2 and TCF4 conferring risk of schizophrenia
260 _ _ |a Oxford
|b Oxford Univ. Press
|c 2011
300 _ _ |a 4076 - 4081
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |0 9913
|a Human Molecular Genetics
|v 20
|x 0964-6906
|y 20
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a This work was supported by the European Union [grant numbers LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene), HEALTH-F2-2009-223423 (Project PsychCNVs)]; the National Genome Research Network of the German Federal Ministry of Education and Research (BMBF) [grant numbers 01GS08144 (MooDS-Net), 01GS08147 (NGFNplus)]; the National Institute of Mental Health [R01 MH078075, and N01 MH900001, MH074027 to the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project]; the Centre of Excellence for Complex Disease Genetics of the Academy of Finland (grant numbers 213506, 129680); the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki; the Stanley Medical Research Institute; the Danish Council for Strategic Research (grant number 2101-07-0059); H. Lundbeck A/S; the Research Council of Norway (grant number 163070/V50); the South-East Norway Health Authority (grant number 2004-123); the Medical Research Council; Ministerio de Sanidad y Consumo, Spain (grant number PI081522 to J.C.); Xunta de Galicia (grant number 08CSA005208PR to A.C.); the Swedish Research Council; the Wellcome Trust (grant number 083948/Z/07/Z as part of the Wellcome Trust Case Control Consortium 2); the Max Planck Society and Eli Lilly and Company (genotyping for CATIE and part of the TOP sample).
520 _ _ |a Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)).
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|0 G:(DE-Juel1)FUEK409
|c P33
|2 G:(DE-HGF)
|x 0
536 _ _ |a PSYCHGENE - Copy Number Variation and Endophenotypes in Psychiatric Disorders (218251)
|0 G:(EU-Grant)218251
|c 218251
|x 1
|f FP7-PEOPLE-2007-3-1-IAPP
536 _ _ |a PSYCHCNVS - Copy number variations conferring risk of psychiatric disorders in children (223423)
|0 G:(EU-Grant)223423
|c 223423
|x 2
|f FP7-HEALTH-2007-B
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Alleles
650 _ 2 |2 MeSH
|a Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: genetics
650 _ 2 |2 MeSH
|a Genetic Predisposition to Disease
650 _ 2 |2 MeSH
|a Genome-Wide Association Study
650 _ 2 |2 MeSH
|a Genotype
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Polymorphism, Single Nucleotide
650 _ 2 |2 MeSH
|a Protein-Serine-Threonine Kinases: genetics
650 _ 2 |2 MeSH
|a Risk
650 _ 2 |2 MeSH
|a Schizophrenia: genetics
650 _ 2 |2 MeSH
|a Transcription Factors: genetics
650 _ 7 |0 0
|2 NLM Chemicals
|a Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
650 _ 7 |0 0
|2 NLM Chemicals
|a TCF4 protein, human
650 _ 7 |0 0
|2 NLM Chemicals
|a Transcription Factors
650 _ 7 |0 EC 2.7.11.1
|2 NLM Chemicals
|a Protein-Serine-Threonine Kinases
650 _ 7 |0 EC 2.7.11.1
|2 NLM Chemicals
|a VRK2 protein, human
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-Juel1)VDB90383
|a et, al.
|b 1
|u FZJ
773 _ _ |0 PERI:(DE-600)1474816-2
|a 10.1093/hmg/ddr325
|g Vol. 20, p. 4076 - 4081
|p 4076 - 4081
|q 20<4076 - 4081
|t Human molecular genetics
|v 20
|x 0964-6906
|y 2011
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298077
909 C O |o oai:juser.fz-juelich.de:17360
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|l Decoding the Human Brain
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914 1 _ |y 2011
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