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000017390 084__ $$2WoS$$aPhysics, Atomic, Molecular & Chemical
000017390 084__ $$2WoS$$aSpectroscopy
000017390 1001_ $$0P:(DE-Juel1)VDB95269$$aOsterholt, T.$$b0$$uFZJ
000017390 245__ $$aIMAGENA: Image Generation and Analysis - An Interactive Software Tool handling LA-ICP MS Data
000017390 260__ $$a[S.l.]$$bElsevier Science$$c2011
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000017390 440_0 $$02787$$aInternational Journal of Mass Spectrometry$$v307$$x1387-3806$$y1
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000017390 520__ $$aMetals are involved in many processes of life. They are needed for enzymatic reactions, are involved in healthy processes but also yield diseases if the metal homeostasis is disordered. Therefore, the interest to assess the spatial distribution of metals is rising in biomedical science. Imaging metal (and non-metal) isotopes by laser ablation mass spectrometry with inductively coupled plasma (LA-ICP-MS) requires a special software solution to process raw data obtained by scanning a sample line-by-line. As no software ready to use was available we developed an interactive software tool for Image Generation and Analysis (IMAGENA). Unless optimised for LA-ICP-MS, IMAGENA can handle other raw data as well. The general purpose was to reconstruct images from a continuous list of raw data points, to visualise these images, and to convert them into a commonly readable image file format that can be further analysed by standard image analysis software. The generation of the image starts with loading a text file that holds a data column of every measured isotope. Specifying general spatial domain settings like the data offset and the image dimensions is done by the user getting a direct feedback by means of a preview image. IMAGENA provides tools for calibration and to correct for a signal drift in the y-direction. Images are visualised in greyscale as well a pseudo-colours with possibilities for contrast enhancement. Image analysis is performed in terms of smoothed line plots in row and column direction. (C) 2011 Elsevier B.V. All rights reserved.
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000017390 65320 $$2Author$$aLA-ICP-MS
000017390 65320 $$2Author$$aImage generation
000017390 65320 $$2Author$$aImage analysis
000017390 65320 $$2Author$$aGraphical user interface
000017390 7001_ $$0P:(DE-HGF)0$$aSalber, D.$$b1
000017390 7001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b2$$uFZJ
000017390 7001_ $$0P:(DE-Juel1)VDB96675$$aBecker, J.S.$$b3$$uFZJ
000017390 7001_ $$0P:(DE-HGF)0$$aPalm, C.$$b4
000017390 773__ $$0PERI:(DE-600)1484635-4$$a10.1016/j.ijms.2011.03.0110$$gVol. 307$$q307$$tInternational journal of mass spectrometry$$v307$$x1387-3806$$y2011
000017390 8567_ $$uhttp://dx.doi.org/10.1016/j.ijms.2011.03.0110
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000017390 9132_ $$0G:(DE-HGF)POF3-574$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vTheory, modelling and simulation$$x0
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