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@ARTICLE{Osterholt:17390,
      author       = {Osterholt, T. and Salber, D. and Matusch, A. and Becker,
                      J.S. and Palm, C.},
      title        = {{IMAGENA}: {I}mage {G}eneration and {A}nalysis - {A}n
                      {I}nteractive {S}oftware {T}ool handling {LA}-{ICP} {MS}
                      {D}ata},
      journal      = {International journal of mass spectrometry},
      volume       = {307},
      issn         = {1387-3806},
      address      = {[S.l.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-17390},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Metals are involved in many processes of life. They are
                      needed for enzymatic reactions, are involved in healthy
                      processes but also yield diseases if the metal homeostasis
                      is disordered. Therefore, the interest to assess the spatial
                      distribution of metals is rising in biomedical science.
                      Imaging metal (and non-metal) isotopes by laser ablation
                      mass spectrometry with inductively coupled plasma
                      (LA-ICP-MS) requires a special software solution to process
                      raw data obtained by scanning a sample line-by-line. As no
                      software ready to use was available we developed an
                      interactive software tool for Image Generation and Analysis
                      (IMAGENA). Unless optimised for LA-ICP-MS, IMAGENA can
                      handle other raw data as well. The general purpose was to
                      reconstruct images from a continuous list of raw data
                      points, to visualise these images, and to convert them into
                      a commonly readable image file format that can be further
                      analysed by standard image analysis software. The generation
                      of the image starts with loading a text file that holds a
                      data column of every measured isotope. Specifying general
                      spatial domain settings like the data offset and the image
                      dimensions is done by the user getting a direct feedback by
                      means of a preview image. IMAGENA provides tools for
                      calibration and to correct for a signal drift in the
                      y-direction. Images are visualised in greyscale as well a
                      pseudo-colours with possibilities for contrast enhancement.
                      Image analysis is performed in terms of smoothed line plots
                      in row and column direction. (C) 2011 Elsevier B.V. All
                      rights reserved.},
      keywords     = {J (WoSType)},
      cin          = {INM-1 / INM-2 / INM-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-4-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89574 - Theory, modelling and simulation (POF2-89574)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89574},
      shelfmark    = {Physics, Atomic, Molecular $\&$ Chemical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000295864100032},
      doi          = {10.1016/j.ijms.2011.03.0110},
      url          = {https://juser.fz-juelich.de/record/17390},
}