TY  - JOUR
AU  - Herold, C.
AU  - Palomero-Gallagher, N.
AU  - Güntürkün, O.
AU  - Zilles, K.
TI  - Serotonin 5-HT1A Receptor Binding Sites in the Brain of the Pigeon (Columba livia)
JO  - Neuroscience
VL  - 200
SN  - 0306-4522
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-17573
SP  - 1 - 12
PY  - 2012
N1  - Supported by a grant from the BMBF through the Bernstein Focus Group "Varying Tunes" to OG.
AB  - Present knowledge about the serotonergic system in birdbrains is very limited, although the pigeon was used as an animal model in various studies focused on the behavioral effects of serotonergic transmission. In the mammalian brain the 5-HT(1A) receptor is the most widespread serotonin receptor type, and is involved in various functions. Less is known about the distribution of 5-HT(1A) receptors in the avian species. Therefore, we analyzed serotonin 5-HT(1A) receptor binding sites in the pigeon brain using quantitative in vitro receptor autoradiography with the selective radioligand [³H]-8-hydroxy-2-(di-n-propylamino)tetralin ([³H]-8-OH-DPAT). The receptor is differentially distributed throughout the pigeon brain. High levels of 5-HT(1A) receptors are found in the nucleus pretectalis (PT). Moderate densities were detected in the tectum, as well as in the telencephalic nidopallium and hyperpallium. Very low levels were found in the hippocampal formation, the amygdaloid complex, the basal ganglia, and several thalamic nuclei. Furthermore, local variations in 5-HT(1A) receptor densities support the concept of further subdivisions of the entopallium. The regional distribution patterns of 5-HT(1A) receptors mostly display a similar distribution as found in homologue brain structures of mammals.
KW  - 8-Hydroxy-2-(di-n-propylamino)tetralin: pharmacokinetics
KW  - Analysis of Variance
KW  - Animals
KW  - Autoradiography
KW  - Binding Sites: drug effects
KW  - Binding Sites: physiology
KW  - Brain: drug effects
KW  - Brain: metabolism
KW  - Brain Mapping
KW  - Columbidae
KW  - Receptors, Serotonin, 5-HT1: metabolism
KW  - Serotonin Receptor Agonists: pharmacokinetics
KW  - Tritium: pharmacokinetics
KW  - Receptors, Serotonin, 5-HT1 (NLM Chemicals)
KW  - Serotonin Receptor Agonists (NLM Chemicals)
KW  - Tritium (NLM Chemicals)
KW  - 8-Hydroxy-2-(di-n-propylamino)tetralin (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22100786
UR  - <Go to ISI:>//WOS:000299302300001
DO  - DOI:10.1016/j.neuroscience.2011.10.050
UR  - https://juser.fz-juelich.de/record/17573
ER  -