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@ARTICLE{Axer:17939,
      author       = {Axer, H. and Beck, S. and Axer, M. and Schuchardt, F. and
                      Heepe, J. and Flucken, A. and Axer, M. and Prescher, A. and
                      Witte, O.W.},
      title        = {{M}icrostructural {A}nalysis of {H}uman {W}hite {M}atter
                      {A}rchitecture {U}sing {P}olarized {L}ight {I}maging:
                      {V}iews from {N}euroanatomy},
      journal      = {Frontiers in Neuroinformatics},
      volume       = {5},
      issn         = {1662-5196},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {PreJuSER-17939},
      pages        = {1 - 12},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {To date, there are several methods for mapping
                      connectivity, ranging from the macroscopic to molecular
                      scales. However, it is difficult to integrate this
                      multiply-scaled data into one concept. Polarized light
                      imaging (PLI) is a method to quantify fiber orientation in
                      gross histological brain sections based on the birefringent
                      properties of the myelin sheaths. The method is capable of
                      imaging fiber orientation of larger-scale architectural
                      patterns with higher detail than diffusion MRI of the human
                      brain. PLI analyses light transmission through a gross
                      histological section of a human brain under rotation of a
                      polarization filter combination. Estimates of the angle of
                      fiber direction and the angle of fiber inclination are
                      automatically calculated at every point of the imaged
                      section. Multiple sections can be assembled into a 3D
                      volume. We describe the principles of PLI and present
                      several studies of fiber anatomy as a synopsis of PLI: six
                      brainstems were serially sectioned, imaged with PLI, and 3D
                      reconstructed. Pyramidal tract and lemniscus medialis were
                      segmented in the PLI datasets. PLI data from the internal
                      capsule was related to results from confocal laser scanning
                      microscopy, which is a method of smaller scale fiber
                      anatomy. PLI fiber architecture of the extreme capsule was
                      compared to macroscopical dissection, which represents a
                      method of larger-scale anatomy. The microstructure of the
                      anterior human cingulum bundle was analyzed in serial
                      sections of six human brains. PLI can generate highly
                      resolved 3D datasets of fiber orientation of the human brain
                      and has high comparability to diffusion MR. To get
                      additional information regarding axon structure and density,
                      PLI can also be combined with classical histological stains.
                      It brings the directional aspects of diffusion MRI into the
                      range of histology and may represent a promising tool to
                      close the gap between larger-scale diffusion orientation and
                      microstructural histological analysis of connectivity.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22110430},
      pmc          = {pmc:PMC3215979},
      doi          = {10.3389/fninf.2011.00028},
      url          = {https://juser.fz-juelich.de/record/17939},
}