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000018200 0247_ $$2DOI$$a10.1074/jbc.M110.209130
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000018200 084__ $$2WoS$$aBiochemistry & Molecular Biology
000018200 1001_ $$0P:(DE-HGF)0$$aWu, Z.$$b0
000018200 245__ $$aThe low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering
000018200 260__ $$aBethesda, Md.$$bSoc.$$c2011
000018200 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000018200 440_0 $$03091$$aJournal of Biological Chemistry$$v286$$x0021-9258$$y12495 - 12508
000018200 500__ $$aThis work was supported, in whole or in part, by National Institutes of Health Grants P01 HL098055, P01 HL076491-055328, and P01 HL087018-02001. This work was also supported in part by a grant from the Foundation Leducq.
000018200 520__ $$aSpherical high density lipoprotein (sHDL), a key player in reverse cholesterol transport and the most abundant form of HDL, is associated with cardiovascular diseases. Small angle neutron scattering with contrast variation was used to determine the solution structure of protein and lipid components of reconstituted sHDL. Apolipoprotein A1, the major protein of sHDL, forms a hollow structure that cradles a central compact lipid core. Three apoA1 chains are arranged within the low resolution structure of the protein component as one of three possible global architectures: (i) a helical dimer with a hairpin (HdHp), (ii) three hairpins (3Hp), or (iii) an integrated trimer (iT) in which the three apoA1 monomers mutually associate over a portion of the sHDL surface. Cross-linking and mass spectrometry analyses help to discriminate among the three molecular models and are most consistent with the HdHp overall architecture of apoA1 within sHDL.
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000018200 650_2 $$2MeSH$$aApolipoprotein A-I: chemistry
000018200 650_2 $$2MeSH$$aHumans
000018200 650_2 $$2MeSH$$aLipoproteins, HDL: chemistry
000018200 650_2 $$2MeSH$$aMass Spectrometry
000018200 650_2 $$2MeSH$$aNeutrons
000018200 650_2 $$2MeSH$$aProtein Multimerization
000018200 650_2 $$2MeSH$$aScattering, Small Angle
000018200 650_7 $$00$$2NLM Chemicals$$aApolipoprotein A-I
000018200 650_7 $$00$$2NLM Chemicals$$aLipoproteins, HDL
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000018200 7001_ $$0P:(DE-HGF)0$$aGogonea, V.$$b1
000018200 7001_ $$0P:(DE-HGF)0$$aLee, X.$$b2
000018200 7001_ $$0P:(DE-HGF)0$$aMay, R.P.$$b3
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000018200 7001_ $$0P:(DE-HGF)0$$aWagner, M.A.$$b5
000018200 7001_ $$0P:(DE-HGF)0$$aUndurti, A.$$b6
000018200 7001_ $$0P:(DE-HGF)0$$aTallant, T.C.$$b7
000018200 7001_ $$0P:(DE-HGF)0$$aBaleanu-Gogonea, C.$$b8
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000018200 7001_ $$0P:(DE-HGF)0$$aDiDonato, J.A.$$b11
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