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000018219 0247_ $$2pmid$$apmid:21972868
000018219 0247_ $$2DOI$$a10.1021/jp2066138
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000018219 084__ $$2WoS$$aChemistry, Physical
000018219 1001_ $$0P:(DE-Juel1)VDB72696$$aWang, W.$$b0$$uFZJ
000018219 245__ $$aRelaxation behavior study of ultra-small superparamagnetic iron oxide nanoparticles at ultra-low and ultra-high magnetic fields
000018219 260__ $$aWashington, DC$$bSoc.$$c2011
000018219 300__ $$a14789 - 14793
000018219 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000018219 440_0 $$03694$$aJournal of Physical Chemistry B$$v115$$x1520-6106$$y49
000018219 500__ $$aWe would like to thank F. Dorn for TEM imaging, J. Bachhausen for IR measurements, and H. Lippert for the ICP-OES measurements. This work is supported by the Research Center Juelich, the China Scholarship Council (CSC), and the German Helmholtz Association.
000018219 520__ $$aUltrasmall superparamagnetic iron oxide nanoparticles (USPIOs) have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR). USPIOs are usually used for their significant capacity to produce predominant proton relaxation effects, which result in signal reduction. However, most previous studies that utilized USPIOs have been focused on the relaxation behavior at commonly used magnetic fields of clinical MRI systems (typically 1-3 T). In this paper, magnetic relaxation processes of protons in water surrounding the USPIOs are studied at ultralow (≤10 mT) and ultrahigh magnetic fields (14.1 T). USPIOs used in our experiments were synthesized with a core size of 6 nm, and transferred from organic to water by ligand exchange. The proton spin-lattice relaxation time (T(1)) and spin-spin relaxation time (T(2)) were investigated at ultralow (212 μT for T(2) and 10 mT for T(1)) and at 14.1 T with different iron concentrations. At all of the fields, there is a linear relationship between the inverse of relaxation times and the iron concentration. The spin-spin relaxivity (r(2)) at 14.1 T is much larger than that value of the ultralow field. At ultralow field, however, the spin-lattice relaxivity (r(1)) is larger than the r(1) at ultrahigh field. The results provide a perspective on potential in vivo and in vitro applications of USPIOs in ultralow and ultrahigh field NMR and MRI.
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000018219 588__ $$aDataset connected to Web of Science, Pubmed
000018219 650_2 $$2MeSH$$aContrast Media: chemistry
000018219 650_2 $$2MeSH$$aFerric Compounds: chemistry
000018219 650_2 $$2MeSH$$aMagnetic Fields
000018219 650_2 $$2MeSH$$aMagnetite Nanoparticles: chemistry
000018219 650_2 $$2MeSH$$aSolubility
000018219 650_2 $$2MeSH$$aWater: chemistry
000018219 650_7 $$00$$2NLM Chemicals$$aContrast Media
000018219 650_7 $$00$$2NLM Chemicals$$aFerric Compounds
000018219 650_7 $$00$$2NLM Chemicals$$aMagnetite Nanoparticles
000018219 650_7 $$01309-37-1$$2NLM Chemicals$$aferric oxide
000018219 650_7 $$07732-18-5$$2NLM Chemicals$$aWater
000018219 650_7 $$2WoSType$$aJ
000018219 7001_ $$0P:(DE-HGF)0$$aDong, H.$$b1
000018219 7001_ $$0P:(DE-Juel1)VDB70443$$aPacheco, V.$$b2$$uFZJ
000018219 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b3$$uFZJ
000018219 7001_ $$0P:(DE-Juel1)VDB5476$$aZhang, Y.$$b4$$uFZJ
000018219 7001_ $$0P:(DE-HGF)0$$aOffenhäusser, A.$$b5
000018219 7001_ $$0P:(DE-Juel1)VDB57647$$aHartmann, R.$$b6$$uFZJ
000018219 7001_ $$0P:(DE-HGF)0$$aWeirich, T.$$b7
000018219 7001_ $$0P:(DE-Juel1)VDB84828$$aMa, P.$$b8$$uFZJ
000018219 7001_ $$0P:(DE-HGF)0$$aKrause, H. J.$$b9
000018219 7001_ $$0P:(DE-HGF)0$$aGu, Z.$$b10
000018219 773__ $$0PERI:(DE-600)2006039-7$$a10.1021/jp2066138$$gVol. 115, p. 14789 - 14793$$p14789 - 14793$$q115<14789 - 14793$$tThe @journal of physical chemistry <Washington, DC> / B$$v115$$x1520-6106$$y2011
000018219 8567_ $$uhttp://dx.doi.org/10.1021/jp2066138
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