000018243 001__ 18243
000018243 005__ 20191125143914.0
000018243 0247_ $$2pmid$$apmid:22232597
000018243 0247_ $$2pmc$$apmc:PMC3248698
000018243 0247_ $$2DOI$$a10.3389/fninf.2011.00034
000018243 0247_ $$2ISSN$$a1662-5196
000018243 0247_ $$2altmetric$$aaltmetric:819221
000018243 037__ $$aPreJuSER-18243
000018243 041__ $$aeng
000018243 082__ $$a610
000018243 1001_ $$0P:(DE-Juel1)VDB67318$$aAxer, M.$$b0$$uFZJ
000018243 245__ $$aHigh-resolution fiber tract reconstruction in the human brain by means of the three-dimensional polarized light imaging (3D-PLI)
000018243 260__ $$aLausanne$$bFrontiers Research Foundation$$c2011
000018243 300__ $$a1-13
000018243 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000018243 3367_ $$2DataCite$$aOutput Types/Journal article
000018243 3367_ $$00$$2EndNote$$aJournal Article
000018243 3367_ $$2BibTeX$$aARTICLE
000018243 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000018243 3367_ $$2DRIVER$$aarticle
000018243 440_0 $$021024$$aFrontiers in Neuroinformatics$$v5$$x1662-5196$$y34
000018243 500__ $$3POF3_Assignment on 2016-02-29
000018243 500__ $$aRecord converted from VDB: 12.11.2012
000018243 520__ $$aFunctional interactions between different brain regions require connecting fiber tracts, the structural basis of the human connectome. To assemble a comprehensive structural understanding of neural network elements from the microscopic to the macroscopic dimensions, a multimodal and multiscale approach has to be envisaged. However, the integration of results from complementary neuroimaging techniques poses a particular challenge. In this paper, we describe a steadily evolving neuroimaging technique referred to as three-dimensional polarized light imaging (3D-PLI). It is based on the birefringence of the myelin sheaths surrounding axons, and enables the high-resolution analysis of myelinated axons constituting the fiber tracts. 3D-PLI provides the mapping of spatial fiber architecture in the postmortem human brain at a sub-millimeter resolution, i.e., at the mesoscale. The fundamental data structure gained by 3D-PLI is a comprehensive 3D vector field description of fibers and fiber tract orientations - the basis for subsequent tractography. To demonstrate how 3D-PLI can contribute to unravel and assemble the human connectome, a multiscale approach with the same technology was pursued. Two complementary state-of-the-art polarimeters providing different sampling grids (pixel sizes of 100 and 1.6 μm) were used. To exemplarily highlight the potential of this approach, fiber orientation maps and 3D fiber models were reconstructed in selected regions of the brain (e.g., Corpus callosum, Internal capsule, Pons). The results demonstrate that 3D-PLI is an ideal tool to serve as an interface between the microscopic and macroscopic levels of organization of the human connectome.
000018243 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000018243 588__ $$aDataset connected to Pubmed
000018243 7001_ $$0P:(DE-Juel1)131642$$aGraessel, D.$$b1$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)VDB100171$$aKleiner, M.$$b2$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)VDB261$$aDammers, J.$$b3$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)165746$$aDickscheid, T.$$b4$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)142294$$aReckfort, J.$$b5$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)VDB103103$$aHuetz, T.$$b6$$uFZJ
000018243 7001_ $$0P:(DE-HGF)0$$aEiben, B.$$b7
000018243 7001_ $$0P:(DE-Juel1)VDB2211$$aPietrzyk, U.$$b8$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b9$$uFZJ
000018243 7001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b10$$uFZJ
000018243 773__ $$0PERI:(DE-600)2452979-5$$a10.3389/fninf.2011.00034$$gVol. 5, p. 1-13$$p1-13$$q5<1-13$$tFrontiers in Neuroinformatics$$v5$$x1662-5196$$y2011
000018243 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248698
000018243 909CO $$ooai:juser.fz-juelich.de:18243$$pVDB
000018243 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aMedline
000018243 915__ $$0StatID:(DE-HGF)0020$$2StatID$$aNo Peer Review
000018243 915__ $$0StatID:(DE-HGF)0020$$2StatID$$aNo Peer Review
000018243 915__ $$0StatID:(DE-HGF)0020$$2StatID$$aNo Peer Review
000018243 915__ $$0StatID:(DE-HGF)0020$$2StatID$$aNo Peer Review
000018243 9141_ $$y2011
000018243 9131_ $$0G:(DE-Juel1)FUEK409$$bGesundheit$$kP33$$lFunktion und Dysfunktion des Nervensystems$$vFunktion und Dysfunktion des Nervensystems$$x0
000018243 9132_ $$0G:(DE-HGF)POF3-579H$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vAddenda$$x0
000018243 9201_ $$0I:(DE-Juel1)INM-1-20090406$$gINM$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x1
000018243 9201_ $$0I:(DE-Juel1)INM-2-20090406$$gINM$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000018243 970__ $$aVDB:(DE-Juel1)132901
000018243 980__ $$aVDB
000018243 980__ $$aConvertedRecord
000018243 980__ $$ajournal
000018243 980__ $$aI:(DE-Juel1)INM-1-20090406
000018243 980__ $$aI:(DE-Juel1)INM-2-20090406
000018243 980__ $$aUNRESTRICTED
000018243 981__ $$aI:(DE-Juel1)INM-2-20090406