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@ARTICLE{Axer:18243,
      author       = {Axer, M. and Graessel, D. and Kleiner, M. and Dammers, J.
                      and Dickscheid, T. and Reckfort, J. and Huetz, T. and Eiben,
                      B. and Pietrzyk, U. and Zilles, K. and Amunts, K.},
      title        = {{H}igh-resolution fiber tract reconstruction in the human
                      brain by means of the three-dimensional polarized light
                      imaging (3{D}-{PLI})},
      journal      = {Frontiers in Neuroinformatics},
      volume       = {5},
      issn         = {1662-5196},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {PreJuSER-18243},
      pages        = {1-13},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Functional interactions between different brain regions
                      require connecting fiber tracts, the structural basis of the
                      human connectome. To assemble a comprehensive structural
                      understanding of neural network elements from the
                      microscopic to the macroscopic dimensions, a multimodal and
                      multiscale approach has to be envisaged. However, the
                      integration of results from complementary neuroimaging
                      techniques poses a particular challenge. In this paper, we
                      describe a steadily evolving neuroimaging technique referred
                      to as three-dimensional polarized light imaging (3D-PLI). It
                      is based on the birefringence of the myelin sheaths
                      surrounding axons, and enables the high-resolution analysis
                      of myelinated axons constituting the fiber tracts. 3D-PLI
                      provides the mapping of spatial fiber architecture in the
                      postmortem human brain at a sub-millimeter resolution, i.e.,
                      at the mesoscale. The fundamental data structure gained by
                      3D-PLI is a comprehensive 3D vector field description of
                      fibers and fiber tract orientations - the basis for
                      subsequent tractography. To demonstrate how 3D-PLI can
                      contribute to unravel and assemble the human connectome, a
                      multiscale approach with the same technology was pursued.
                      Two complementary state-of-the-art polarimeters providing
                      different sampling grids (pixel sizes of 100 and 1.6 μm)
                      were used. To exemplarily highlight the potential of this
                      approach, fiber orientation maps and 3D fiber models were
                      reconstructed in selected regions of the brain (e.g., Corpus
                      callosum, Internal capsule, Pons). The results demonstrate
                      that 3D-PLI is an ideal tool to serve as an interface
                      between the microscopic and macroscopic levels of
                      organization of the human connectome.},
      cin          = {INM-1 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22232597},
      pmc          = {pmc:PMC3248698},
      doi          = {10.3389/fninf.2011.00034},
      url          = {https://juser.fz-juelich.de/record/18243},
}