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000018246 0247_ $$2pmid$$apmid:21331396
000018246 0247_ $$2DOI$$a10.1039/c0an01048k
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000018246 084__ $$2WoS$$aChemistry, Analytical
000018246 1001_ $$0P:(DE-HGF)0$$aGlöggler, S.$$b0
000018246 245__ $$aSelective drug trace detection with low-field NMR
000018246 260__ $$aCambridge$$bSoc.$$c2011
000018246 300__ $$a1566 - 1568
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000018246 520__ $$aAdvances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.
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000018246 650_2 $$2MeSH$$aDrug Residues: analysis
000018246 650_2 $$2MeSH$$aHarmine: analysis
000018246 650_2 $$2MeSH$$aHydrogen: chemistry
000018246 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy: methods
000018246 650_2 $$2MeSH$$aMorphine: analysis
000018246 650_2 $$2MeSH$$aNicotine: analysis
000018246 650_2 $$2MeSH$$aOpium: chemistry
000018246 650_2 $$2MeSH$$aTobacco: chemistry
000018246 650_7 $$01333-74-0$$2NLM Chemicals$$aHydrogen
000018246 650_7 $$0442-51-3$$2NLM Chemicals$$aHarmine
000018246 650_7 $$054-11-5$$2NLM Chemicals$$aNicotine
000018246 650_7 $$057-27-2$$2NLM Chemicals$$aMorphine
000018246 650_7 $$08008-60-4$$2NLM Chemicals$$aOpium
000018246 650_7 $$2WoSType$$aJ
000018246 7001_ $$0P:(DE-Juel1)VDB103106$$aEmondts, M.$$b1$$uFZJ
000018246 7001_ $$0P:(DE-Juel1)VDB103107$$aColell, J.$$b2$$uFZJ
000018246 7001_ $$0P:(DE-Juel1)VDB1099$$aMueller, R.$$b3$$uFZJ
000018246 7001_ $$0P:(DE-HGF)0$$aBlümich, B.$$b4
000018246 7001_ $$0P:(DE-Juel1)133861$$aAppelt, S.$$b5$$uFZJ
000018246 773__ $$0PERI:(DE-600)1472713-4$$a10.1039/c0an01048k$$gVol. 136, p. 1566 - 1568$$p1566 - 1568$$q136<1566 - 1568$$tThe @analyst$$v136$$x0003-2654$$y2011
000018246 8567_ $$uhttp://dx.doi.org/10.1039/c0an01048k
000018246 8564_ $$uhttps://juser.fz-juelich.de/record/18246/files/FZJ-18246.pdf$$yPublished under German "Allianz" Licensing conditions on 2011-02-17. Available in OpenAccess from 2012-02-17$$zPublished final document.
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