TY  - JOUR
AU  - Glöggler, S.
AU  - Emondts, M.
AU  - Colell, J.
AU  - Mueller, R.
AU  - Blümich, B.
AU  - Appelt, S.
TI  - Selective drug trace detection with low-field NMR
JO  - The analyst
VL  - 136
SN  - 0003-2654
CY  - Cambridge
PB  - Soc.
M1  - PreJuSER-18246
SP  - 1566 - 1568
PY  - 2011
N1  - Record converted from VDB: 12.11.2012
AB  - Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.
KW  - Drug Residues: analysis
KW  - Harmine: analysis
KW  - Hydrogen: chemistry
KW  - Magnetic Resonance Spectroscopy: methods
KW  - Morphine: analysis
KW  - Nicotine: analysis
KW  - Opium: chemistry
KW  - Tobacco: chemistry
KW  - Hydrogen (NLM Chemicals)
KW  - Harmine (NLM Chemicals)
KW  - Nicotine (NLM Chemicals)
KW  - Morphine (NLM Chemicals)
KW  - Opium (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21331396
UR  - <Go to ISI:>//WOS:000288864000004
DO  - DOI:10.1039/c0an01048k
UR  - https://juser.fz-juelich.de/record/18246
ER  -