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@ARTICLE{Glggler:18246,
author = {Glöggler, S. and Emondts, M. and Colell, J. and Mueller,
R. and Blümich, B. and Appelt, S.},
title = {{S}elective drug trace detection with low-field {NMR}},
journal = {The analyst},
volume = {136},
issn = {0003-2654},
address = {Cambridge},
publisher = {Soc.},
reportid = {PreJuSER-18246},
pages = {1566 - 1568},
year = {2011},
note = {Record converted from VDB: 12.11.2012},
abstract = {Advances with para-hydrogen induced polarization open up
new fields of applications for portable low-field NMR. Here
we report the possibility of tracing drugs down to the
micromolar regime. We could selectively polarize nicotine
quantities similar to those found in one cigarette. Also
less than 1 mg of harmine, a drug used for treatment of
Parkinson's disease, and morphine extracted from an opium
solution were detectable after polarization with
para-hydrogen in single-scan (1)H-experiments. Moreover, we
demonstrate the possibility to selectively enhance and
detect the (1)H-signal of drug molecules with PHIP in proton
rich standard solutions that would otherwise mask the (1)H
NMR signal of the drug.},
keywords = {Drug Residues: analysis / Harmine: analysis / Hydrogen:
chemistry / Magnetic Resonance Spectroscopy: methods /
Morphine: analysis / Nicotine: analysis / Opium: chemistry /
Tobacco: chemistry / Hydrogen (NLM Chemicals) / Harmine (NLM
Chemicals) / Nicotine (NLM Chemicals) / Morphine (NLM
Chemicals) / Opium (NLM Chemicals) / J (WoSType)},
cin = {ZEL},
ddc = {540},
cid = {I:(DE-Juel1)ZEL-20090406},
pnm = {ohne FE},
pid = {G:(DE-Juel1)FUEK307},
shelfmark = {Chemistry, Analytical},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:21331396},
UT = {WOS:000288864000004},
doi = {10.1039/c0an01048k},
url = {https://juser.fz-juelich.de/record/18246},
}